Page 109 - GPD-4-1

Gene & Protein in Disease

ORIGINAL RESEARCH ARTICLE
Correlation between SIRT1 expression and

overall survival across various cancers: A
meta-analysis

Name ORCID Mehreen Iftikhar , Sana Tanveer , Samyyia Abrar , Amna Rehman ,
1†
3†
2†
1†
Ali Afzal https://orcid.org/0000-0003-3679-1257 Shaaf Ahmad , Umair Ali Khan Saddozai , Faiqa Irshad , Kaleem Maqsood ,
4
5
1
3
Xin-Ying Ji https://orcid.org/0000-0003-0690-4206 Ali Afzal * , Xin-Ying Ji * , and Muhammad Babar Khawar *
5,6
7,8
1,5
Muhammad Babar Khawar https://orcid.org/0000-0002-1812-0591
1 Department of Zoology, Applied Molecular Biology and Biomedicine Lab, Faculty of Sciences,
University of Narowal, Narowal, Punjab, Pakistan
2 Department of Biological Sciences, Faculty of Allied Health Sciences, The Superior University,
Lahore, Punjab, Pakistan
3 Institute of Zoology, University of the Punjab, Lahore, Punjab, Pakistan
4 King Edward Medical University, Lahore, Punjab, Pakistan
5 Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, China
6 Molecular Medicine and Cancer Therapeutics Lab, Faculty of Sciences and Technology, University
of Central Punjab, Lahore, Punjab, Pakistan
† These authors contributed equally
to this study. Abstract
*Corresponding authors:
Muhammad Babar Khawar Sirtuin 1 (SIRT1) plays a complex role in cancer, significantly influencing cancer
(babarkhawar@yahoo.com)
Xinying Ji prognosis. However, its true impact remains unclear, necessitating a comprehensive
(10190096@vip.henu.edu.cn) and unified analysis. This study investigates the prognostic value of SIRT1 expression
Ali Afzal across different cancers worldwide. Relevant studies were retrieved from Google
(aliafzal2615@gmail.com)
Scholar, PubMed, and Web of Science. Only human studies exploring the prognostic
Citation: Iftikhar M, Tanveer S, role of SIRT1 in various cancers were included in the study. Data on patient
Abrar S, et al. Correlation between
SIRT1 expression and overall demographics, SIRT1 expression levels, and overall survival (OS) rates were extracted,
survival across various cancers: A followed by subsequent analyses, including meta-regression for heterogeneity
meta-analysis. Gene Protein Dis. and Egger’s regression for publication bias. A total of 15 studies (pooled hazard
2025;4(1):4294.
doi: 10.36922/gpd.4294 ratio = 1.483 ± 0.2974 [95% CI: 0.900 – 2.065]), predominantly from Asia (n = 10), were
selected for the meta-analysis. The analysis demonstrated a robust and consistent
Received: July 21, 2024
1st revised: September 23, 2024 association between elevated SIRT1 expression and poorer OS across diverse
2
2nd revised: October 19, 2024 variables (P < 0.001), with minimal heterogeneity (I = 0.0001). Subgroup analyses
Accepted: October 22, 2024 confirmed significant effects of SIRT1 on OS rates based on regions (Asia: P < 0.001;
Published online: January 7, 2025 non-Asia: P < 0.001), study size (small: P = 0.001, medium: P = 0.002, and large cohorts:
Copyright: © 2025 Author(s). P = 0.021), and specific cancer types (ovarian: P = 0.041, lung: P = 0.025, and gastric
This is an Open-Access article cancer: P = 0.025). However, no significant impact was observed in breast (P = 0.136)
distributed under the terms of the
Creative Commons Attribution and colorectal cancers (P = 0.221). Overall, SIRT1 demonstrates consistent prognostic
License, permitting distribution, significance across various cancers and populations. However, the assessment of
and reproduction in any medium, its long-term prognostic effects remains elusive, highlighting the need for further
provided the original work is
properly cited. mechanistic research to guide targeted interventions and precision medicine in
cancer therapy.
Publisher’s Note: AccScience
Publishing remains neutral with
regard to jurisdictional claims in
published maps and institutional Keywords: Sirtuin; Prognosis; Cancer; Precision medicine; Oncology research
affiliations.

Volume 4 Issue 1 (2025) 1 doi: 10.36922/gpd.4294