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Gene & Protein in Disease Prognostic role of SIRT1 expression in cancer

A B

C D

E F

Figure 3. Bubble plots analyzing various moderators of the studies. Our analysis showed no statistically significant heterogeneity (P = 0.9899) across
(A) Asian versus non-Asian countries, (B) different sample sizes, (C) cancer types included in the current analysis, (D) age groups, (E) tumor stages, and
(F) SIRT1 expression levels.

lung cancer (n = 3, P = 0.025) and gastric cancer (n = 2, effect = 1.5, 95% CI [0.752 – 2.244], P ≤ 0.001) and female
P = 0.025) also showed significant effects with low (overall effect = 1.46, 95% CI [0.524 – 2.393], P = 0.002)
heterogeneity (I = 0.03). In contrast, studies on uterine cohorts, with no observed heterogeneity (I = 0.00).
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2
cancer (n = 2, P = 0.051) and renal cell carcinoma (n = 2, Various tumor stages also showed significant prognostic
P = 0.061) showed trends toward significance, with low value for SIRT1, including stages I–IV (P < 0.001) and I–III
heterogeneity (I = 0.05 and I = 0.06, respectively). & IV (P = 0.013), with low to no heterogeneity.
2
2
However, studies on breast cancer and colorectal cancer
did not show statistically significant results (P = 0.136 and Importantly, the prognostic value of SIRT1 appeared to
P = 0.221, respectively). The prognostic value of SIRT1 also vary based on SIRT1 expression levels in a relatively unique
varied across different age groups. Significant effects were manner. The analysis revealed that studies (n = 10) reporting
observed in the age groups 56 – 60 with no heterogeneity high SIRT1 expression showed highly statistically significant
(I = 0.00) and 61 – 65 with low heterogeneity (I = 0.02). effects (P < 0.001), with no observed heterogeneity
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However, the age groups 50 – 55 and 66 – 70 did not show (I = 0.00%). Conversely, five studies focusing on cancers
statistically significant results (P = 0.161 and P = 0.237, with low SIRT1 expression showed statistically significant
2
respectively). The prognostic effect of SIRT1 remained results (P = 0.011), with a low level of heterogeneity (I
significant and consistent across both male (overall = 0.01%). Overall, the subgroup analyses revealed consistent
Volume 4 Issue 1 (2025) 6 doi: 10.36922/gpd.4294