Page 133 - GPD-4-1

Gene & Protein in Disease In silico insights on fisetin’s antidepressant effects

doi: 10.1002/ptr.7551 mechanisms instead of treating symptoms. Trends
Pharmacol Sci. 2022;43(2):136-150.
10. Zhang W, Huai Y, Miao Z, Qian A, Wang Y. Systems
pharmacology for investigation of the mechanisms of action doi: 10.1016/j.tips.2021.11.004
of traditional Chinese medicine in drug discovery. Front 21. Noor F, Tahir ul Qamar M, Ashfaq UA, Albutti A, Alwashmi
Pharmacol. 2019;10:743.
ASS, Aljasir MA. Network pharmacology approach for
doi: 10.3389/fphar.2019.00743 medicinal plants: Review and assessment. Pharmaceuticals
(Basel). 2022;15(5):572.
11. Qi Z, Xie P, Yang C, et al. Developing fisetin-AgNPs
incorporated in reinforced chitosan/pullulan composite- doi: 10.3390/ph15050572
film and its application of post-harvest storage in litchi fruit. 22. Daina A, Michielin O, Zoete V. SwissTargetPrediction:
Food Chem. 2023;407:135122.
Updated data and new features for efficient prediction
doi: 10.1016/j.foodchem.2022.135122 of protein targets of small molecules. Nucleic Acids Res.
2019;47(W1):W357-W364.
12. Matić S, Stanić S, Mihailović M, Bogojević D. Cotinus
coggygria Scop.: An overview of its chemical constituents, doi: 10.1093/nar/gkz382
pharmacological and toxicological potential. Saudi J Biol Sci. 23. Nickel J, Gohlke BO, Erehman J, et al. SuperPred: Update on
2016;23(4):452-461.
drug classification and target prediction. Nucleic Acids Res.
doi: 10.1016/j.sjbs.2015.05.012 2014;42(W1):W26-W31.
13. Ding H, Li Y, Chen S, et al. Fisetin ameliorates cognitive doi: 10.1093/nar/gku477
impairment by activating mitophagy and suppressing 24. Safran M, Dalah I, Alexander J, et al. GeneCards
neuroinflammation in rats with sepsis‐associated Version 3: The human gene integrator. Database (Oxford).
encephalopathy. CNS Neurosci Ther. 2022;28(2):247-258.
2010;2010:baq020.
doi: 10.1111/cns.13765
doi: 10.1093/database/baq020
14. Wang Y, Wang B, Lu J, et al. Fisetin provides antidepressant 25. Franz M, Lopes CT, Fong D, et al. Cytoscape.js 2023 update:
effects by activating the tropomyosin receptor kinase B A graph theory library for visualization and analysis.
signal pathway in mice. J Neurochem. 2017;143(5):561-568.
Bioinformatics. 2023;39(1):btad031.
doi: 10.1111/jnc.14226
doi: 10.1093/bioinformatics/btad031
15. Yu X, Jiang X, Zhang X, et al. The effects of fisetin on 26. Ge SX, Jung D, Yao R. ShinyGO: A graphical gene-set
lipopolysaccharide-induced depressive-like behavior in enrichment tool for animals and plants. Bioinformatics.
mice. Metab Brain Dis. 2016;31:1011-1021.
2020;36(8):2628-2629.
doi: 10.1007/s11011-016-9839-5
doi: 10.1093/bioinformatics/btz931
16. Kohler O, Krogh J, Mors O, Benros ME. Inflammation 27. Karakuş F, Kuzu B. Predicting the molecular mechanisms of
in depression and the potential for anti-inflammatory cardiovascular toxicity induced by per-and polyfluoroalkyl
treatment. Curr Neuropharmacol. 2016;14(7):732-742.
substances: An in silico network toxicology perspective.
doi: 10.2174/1570159X14666151208113700 Toxicol Res (Camb). 2024;13(6):tfae206.
17. Maher P, Akaishi T, Abe K. Flavonoid fisetin promotes ERK- doi: 10.1093/toxres/tfae206
dependent long-term potentiation and enhances memory. 28. Liu Y, Cao Y. Protein-ligand blind docking using CB-Dock2.
Proc Natl Acad Sci U S A. 2006;103(44):16568-16573.
Methods Mol Biol. 2024;2714:113-125.
doi: 10.1073/pnas.0607822103
doi: 10.1007/978-1-0716-3441-7_6
18. Ishige K, Schubert D, Sagara Y. Flavonoids protect neuronal 29. Liu Y, Yang X, Gan J, Chen S, Xiao ZX, Cao Y. CB-Dock2:
cells from oxidative stress by three distinct mechanisms. Improved protein-ligand blind docking by integrating cavity
Free Radic Biol Med. 2001;30(4):433-446.
detection, docking and homologous template fitting. Nucleic
doi: 10.1016/S0891-5849(00)00498-6 Acids Res. 2022;50(W1):W159-W164.
19. Han X, Yang C, Guo C, et al. Bioinformatics analysis to doi: 10.1093/nar/gkac394
screen key targets of curcumin against colorectal cancer and 30. Arora V, Chopra K. Possible involvement of oxido-
the correlation with tumor‐infiltrating immune cells. Evid nitrosative stress induced neuro-inflammatory cascade and
Based Complement Alternat Med. 2021;2021(1):9132608.
monoaminergic pathway: Underpinning the correlation
doi: 10.1155/2021/9132608 between nociceptive and depressive behaviour in a rodent
model. J Affect Disord. 2013;151(3):1041-1052.
20. Nogales C, Mamdouh ZM, List M, Kiel C, Casas AI,
Schmidt HH. Network pharmacology: Curing causal doi: 10.1016/j.jad.2013.08.032

Volume 4 Issue 1 (2025) 11 doi: 10.36922/gpd.4846