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Gene & Protein in Disease                                          Chinese herbs and stem cells in neurology



            efficiency, minimize side effects, and pave the way for   Diseases. Ch. 9. United States: Academic Press; 2017.
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            remain, including potential immunogenicity, tumorigenic   4.   Mokhtari  T, Shayan M, Rashnudi  AR, Hassanzadeh G,
            risks, and dosage sensitivity for both stem cells and TCM   Nia KM. Wharton’s jelly mesenchymal stem cells attenuate
            ingredients. To harness these benefits and translate them   global hypoxia-induced learning and memory impairment
            into clinical practice, further research should focus on   via preventing blood-brain barrier breakdown. Iran J Basic
            refining combined therapy protocols, optimizing dosage   Med Sci. 2023;26(9):1053.
            and delivery methods, and conducting large-scale trials      doi: 10.22038/IJBMS.2023.70137.15250
            with  rigorous  safety  and efficacy  assessments.  Future
            studies should also establish clear patient selection criteria   5.   Bonaventura G, Munafò A, Bellanca CM, et al. Stem cells:
                                                                  Innovative therapeutic options for neurodegenerative
            and evaluate long-term outcomes to ensure clinical    diseases? Cells. 2021;10(8):1992.
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            neuroregenerative medicine.                           doi: 10.3390/cells10081992
                                                               6.   Mehrannia  K,  Mokhtari  T,  Noori  Mogehi  SMH,  et  al.
            Acknowledgments                                       Intracerebroventricular injection of Wharton’  jelly
            None.                                                 mesenchymal  stem  cells  attenuates  brain  damage  in  rat
                                                                  model of hypoxia: Optimization of vascular endothelial
            Funding                                               growth factor and downregulation of inflammatory factors.
                                                                  J Contemp Med Sci. 2018;4(3): 134-139.
            None.
                                                               7.   Guo Y, Peng Y, Zeng H, Chen G. Progress in mesenchymal
            Conflict of interest                                  stem cell therapy for ischemic stroke.  Stem Cells Int.
                                                                  2021;2021:9923566.
            The authors declare that they have no competing interests.
                                                                  doi: 10.1155/2021/9923566
            Author contributions                               8.   Burns TC, Quinones-Hinojosa A. Regenerative medicine
                                                                  for neurological diseases-will regenerative neurosurgery
            Conceptualization: Shima Mohammadi                    deliver? BMJ. 2021;373:n955.
            Writing – original draft: Romina Kardan, Reyhaneh Ghotbi
            Writing – review & editing: Shima Mohammadi           doi: 10.1136/bmj.n955
                                                               9.   Chiu AY, Rao MSJN. Cell-based therapy for neural
            Ethics approval and consent to participate            disorders-anticipating  challenges.  Neurotherapeutics.
            Not applicable.                                       2011;8(4):744-752.
                                                                  doi: 10.1007/s13311-011-0066-9
            Consent for publication
                                                               10.  Chan SF, Sances S, Brill LM,  et al. ATM-dependent
            Not applicable.                                       phosphorylation of MEF2D promotes neuronal survival
                                                                  after DNA damage. J Neursci. 2014;34(13):4640-4653.
            Availability of data
                                                                  doi: 10.1523/JNEUROSCI.2510-12.2014
            Not applicable.
                                                               11.  Surguchov A, Bernal L and Surguchev AA. Phytochemicals
            References                                            as regulators of genes involved in synucleinopathies.
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            Volume 4 Issue 2 (2025)                         7                               doi: 10.36922/gpd.4835
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