Page 9 - GPD-4-2

Gene & Protein in Disease

REVIEW ARTICLE
Promoting stem cells activity using Chinese

medicine herbs in treatment of neurological
disorder: A review on novel therapeutic

approaches

3
Romina Kardan 1 , Reyhaneh Ghotbi 2 , and Shima Mohammadi *
1 Department of Neurosciences and Addiction Studies, School of Advanced Technologies in Medicine,
Tehran University of Medical Sciences, Tehran, Iran
2 Department of Anatomy, School of Medicine, Tehran University of Medical sciences, Tehran, Iran
3 Department of Neuroscience, School of Medicine, Shahroud University of Medical Sciences,
Shahroud, Iran

Abstract

Stem cell therapy represents a burgeoning and swiftly advancing modality for
the treatment of a diverse array of neurological disorders. However, despite
continued clinical trials, the underlying mechanisms of action often remain elusive.
*Corresponding author: Traditional Chinese medicine (TCM), with its holistic approach, provides a valuable
Shima Mohammadi resource for the identification and evaluation of potential neuroprotective agents.
(mohamadi.sh@shmu.ac.ir) Research has shown that TCM, including herbs, herbal extracts, and specific
Citation: Kardan R, Ghotbi R, Chinese herbal constituents, can modulate the proliferation and differentiation
Mohammadi S. Promoting stem of neural stem cells (NSCs) to some extent. This review examines the potential
cells activity using Chinese
medicine herbs in treatment of of TCM as a treatment for neurodegenerative diseases. Given the limitations of
neurological disorder: A review current therapies due to a lack of understanding of disease pathogenesis, a holistic
on novel therapeutic approaches. approach to TCM offers a promising alternative. This paper also summarizes the
Gene Protein Dis. 2025;4(2):4835.
doi: 10.36922/gpd.4835 role of stem cells in the management of neurological disorders and evaluates
prior studies concerning stem cell transplantation. In addition, it explores the
Received: September 12, 2024
capacity of TCM to influence the proliferation and differentiation of NSCs. The
1st revised: November 12, 2024 ultimate aim of this review is to enhance our understanding of how TCM can be
2nd revised: November 14, 2024 utilized to influence stem cell behavior and potentially treat neurodegenerative
diseases.
Accepted: November 15, 2024
Published online: December 4,
2024 Keywords: Stem cell; Traditional Chinese medicine; Neurodegenerative diseases;
Neuroprotective agents
Copyright: © 2024 Author(s).
This is an Open-Access article
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium, 1. Introduction
provided the original work is
properly cited. Therapeutic strategies aimed at addressing neurological disorders that impact the central
Publisher’s Note: AccScience nervous system (CNS) are frequently constrained by our insufficient comprehension of
Publishing remains neutral with pathophysiology. While certain CNS disorders have a genetic basis or are associated with
regard to jurisdictional claims in
published maps and institutional specific proteins, a significant number entail intricate interactions among diverse cellular
1,2
affiliations. types and metabolites within the cerebral microenvironment. CNS pathologies and

Volume 4 Issue 2 (2025) 1 doi: 10.36922/gpd.4835