Page 69 - GPD-4-3
P. 69
Gene & Protein in Disease Genetic pleiotropy in birth weight and fat
43. Boucher J, Softic S, El Ouaamari A, et al. Differential roles of 53. St-Pierre J, Hivert MF, Perron P, et al. IGF2 DNA methylation
insulin and IGF-1 receptors in adipose tissue development is a modulator of newborn’s fetal growth and development.
and function. Diabetes. 2016;65(8):2201-2213. Epigenetics. 2012;7(10):1125-1132.
doi: 10.2337/db16-0212 doi: 10.4161/epi.21855
44. Lee KY, Russell SJ, Ussar S, et al. Lessons on conditional 54. Faienza MF, Santoro N, Lauciello R, et al. IGF2 gene variants
gene targeting in mouse adipose tissue. Diabetes. and risk of hypertension in obese children and adolescents.
2013;62(3):864-874. Pediatr Res. 2010;67(4):340-344.
doi: 10.2337/db12-1089 doi: 10.1203/PDR.0b013e3181d22757
45. Kentistou KA, Lim BEM, Kaisinger LR, et al. Rare variant 55. Lazou A, Barlaka E. Peroxisome proliferator-activated
associations with birth weight identify genes involved in receptor (PPAR). In: Choi S, editor. Encyclopedia of Signaling
adipose tissue regulation, placental function and insulin- Molecules. New York: Springer; 2016.
like growth factor signalling. Nat Commun. 2025;16(1):648. doi: 10.1007/978-1-4614-6438-9_101829-1
doi: 10.1038/s41467-024-55761-2 56. Wieser F, Waite L, Depoix C, Taylor RN. PPAR action
46. Kempf E, Landgraf K, Vogel T, et al. Associations of GHR, in human placental development and pregnancy and its
IGF-1 and IGFBP-3expression in adipose tissue cells with complications. PPAR Res. 2008;2008:527048.
obesity-related alterations in corresponding circulating doi: 10.1155/2008/527048
levels and adipose tissue function in children. Adipocyte.
2002;11(1):630-642. 57. Guo J, Wu J, He Q, Zhang M, Li H, Liu Y. The potential
role of PPARs in the fetal origins of adult disease. Cells.
doi: 10.1080/21623945.2022.2148886 2022;11(21):3474.
47. Dunger DB, Ong KK, Huxtable SJ, et al. Association of the doi: 10.3390/cells11213474
INS VNTR with size at birth. ALSPAC study team. Avon 58. O’Callaghan JL, Clifton VL, Prentis P, Ewing A, Miller YD,
longitudinal study of pregnancy and childhood. Nat Genet. Pelzer ES. Modulation of placental gene expression in small-
1998;19(1):98-100.
for-gestational-age infants. Genes (Basel). 2020;11(1):80.
doi: 10.1038/ng0598-98
doi: 10.3390/genes11010080
48. Le Stunff C, Fallin D, Bougnères P. Paternal transmission of 59. Díaz M, Bassols J, López-Bermejo A, Gómez-Roig MD,
the very common class I INS VNTR alleles predisposes to De Zegher F, Ibáñez L. Placental expression of peroxisome
childhood obesity. Nat Genet. 2001;29(1):96-99. proliferator-activated receptor γ (PPARγ): Relation to
doi: 10.1038/ng707 placental and fetal growth. J Clin Endocrinol Metab.
2012;97(8):E1468-E1472.
49. Santoro N, Cirillo G, Amato A, et al. Insulin gene variable
number of tandem repeats (INS VNTR) genotype and doi: 10.1210/jc.2012-1064
metabolic syndrome in childhood obesity. J Clin Endocrinol 60. Vidal-Puig AJ, Considine RV, Jimenez-Liñan M, et al.
Metab. 2006;91(11):4641-4644. Peroxisome proliferator-activated receptor gene expression
doi: 10.1210/jc.2005-2705 in human tissues. Effects of obesity, weight loss, and
regulation by insulin and glucocorticoids. J Clin Invest.
50. Kadakia R, Josefson J. The relationship of insulin-like growth 1997;99(10):2416-2422.
factor 2 to fetal growth and adiposity. Horm Res Paediatr.
2016;85(2):75-82. doi: 10.1172/JCI119424
doi: 10.1159/000443500 61. Stienstra R, Duval C, Müller M, et al. PPARs, obesity, and
inflammation. PPAR Res. 2007;2007:95974.
51. Alfares MN, Perks CM, Hamilton-Shield JP, et al.
Insulin-like growth factor-II in adipocyte regulation: doi: 10.1155/2007/95974
Depot-specific actions suggest a potential role limiting 62. Choi SH, Chung SS, Park KS. Re-highlighting the action
excess visceral adiposity. Am J Physiol Endocrinol Metab. of PPARγ in treating metabolic diseases. F1000Res.
2018;315(6):E1098-E1107. 2018;7:F1000 Faculty Rev:1127.
doi: 10.1152/ajpendo.00409.2017 doi: 10.12688/f1000research.14136.1
52. Zhang K, Wang F, Huang J, et al. Insulin-like growth factor 2 63. Li X, Ren Y, Chang K, Wu W, Griffiths HR, Lu S, Gao D.
promotes the adipogenesis of hemangioma-derived stem Adipose tissue macrophages as potential targets for obesity
cells. Exp Ther Med. 2019;17(3):1663-1669. and metabolic diseases. Front Immunol. 2023;4:1153915.
doi: 10.3892/etm.2018.7132 doi: 10.3389/fimmu.2023.1153915
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