Page 27 - GTM-2-4

Global Translational Medicine

REVIEW ARTICLE
The significance of human papillomavirus

integration in carcinogenesis and the
development of specific diagnostics and

countermeasures

2,3
1
1
Jiaxu Ying , Gary Wong *, and Nicolas Berthet *
1 Viral Hemorrhagic Fevers Research Unit, Chinese Academy of Sciences Key Laboratory of
Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy
of Sciences, Shanghai, China
2 Environment and Infectious Risks Research and Expertise Unit, Institut Pasteur,
Université Paris-Cite, Paris, France
3 Epidemiology and Physiopathology of Oncogenic Viruses Unit, Institut Pasteur, Université
Paris-Cite, Paris, France

Abstract
Human papillomavirus (HPV) infection is associated with various tumors, notably in
the cervix, oropharyngeal region, and anus. As the disease progresses, integration
of the viral genome into the host genome is often observed, yet the means of
integration and its intrinsic relationship to carcinogenesis remain unclear. To address
*Corresponding authors: this gap, novel sequencing technologies have been developed to enhance the
Gary Wong accuracy, intuitiveness, and cost-effectiveness of identifying integration breakpoints.
(garyckwong@ips.ac.cn) HPV genome integration is thought to induce imbalances or dysfunctions in gene
Nicolas Berthet
(nicolas.berthet@pasteur.fr) expression, epigenetic changes, chromosomal translocation, and genetic instability.
The precise mechanisms underlying the changes in gene expression caused by
Citation: Ying J, Wong G, genome integration offer avenues for tumor risk prediction and prognosis assessment.
Berthet N, 2023, The significance
of human papillomavirus integration Personalized precision medicine, grounded in the integration patterns unique to
in carcinogenesis and the each patient, holds promise for cancer treatment. This review summarizes and
development of specific diagnostics discusses the current state of knowledge regarding the mechanisms, carcinogenesis,
and countermeasures. Global
Transl Med, 2(4): 2034. detection and analysis, and clinical significance of HPV integration. It synthesizes
https://doi.org/10.36922/gtm.2034 existing information to offer a comprehensive overview, potentially enhancing our
Received: October 13, 2023 understanding of HPV-related tumorigenesis and aiding in the development of more
Accepted: November 30, 2023 effective diagnostic and therapeutic strategies.
Published Online: December 18,
2023
Copyright: © 2023 Author(s). Keywords: Human papillomavirus; Integration mechanism; Carcinogenesis; Integration
This is an Open Access article sites identification; Clinical significance
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium,
provided the original work is 1. Introduction
properly cited.
Globally, cervical cancer ranks as the fourth most common cancer among women, with an
Publisher’s Note: AccScience
Publishing remains neutral with estimated 604,000 new cases reported in 2020. Out of the approximately 342,000 cervical
regard to jurisdictional claims in cancer-related deaths in the same year, roughly 90% were concentrated in low- and
published maps and institutional
[1]
affiliations. middle-income countries . In Africa and Southeast Asia, human papillomavirus (HPV)

Volume 2 Issue 4 (2023) 1 https://doi.org/10.36922/gtm.2034