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Global Translational Medicine Personalized, multi-omics disease detection

A

B C

D

Figure 1. Outline of the iPOP microsampling multi-omics workflow, the molecular changes that occur in response to the consumption of a shake, and
insight into an individual’s physiological status and circadian rhythm. (A) Microsampling devices were used to collect the samples, which were then
subjected to multi-omics analysis involving proteomics, metabolomics, lipidomics, cytokine profiling and other techniques. (B) The multi-omics data
obtained from the microsamples are summarized. (C) The metabolites, lipids and cytokines/hormones were analyzed to determine their response to the
consumption of an Ensure shake, using a two-sided Wilcoxon rank test. (D) Four molecules that are indicative of the participant’s lifestyle and circadian
rhythm are shown. This figure has been modified from Shen et al., which is licensed under a Creative Commons Attribution 4.0 International License.
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7. Vision transformative approach aims to provide personalized, real-
time health assessments and interventions. The following
In the envisioned future of healthcare, the fusion of sections present an expanded vision built on the visions of
wearable technology and multi-omics characterization the iPOP studies, demonstrated with the multiple stages a
promises to revolutionize how we monitor and manage patient enrolled in a phase 3 clinical trial for a new sickle
health at every stage of the healthcare journey. Whether cell disease treatment will undergo, in which the patient is
for a healthy individual seeking proactive health insights, a required to self-administer medication while at home. This
participant in a clinical trial or a patient in a hospital, this vision is summarized and generalized in Figure 2.

Volume 3 Issue 1 (2024) 7 https://doi.org/10.36922/gtm.2357