Page 99 - GTM-3-4

Global Translational Medicine

ORIGINAL RESEARCH ARTICLE
Prediction of in-stent restenosis based on

systematic and retrospective analyses

Alina M. Enikeeva 1,2 , Liutsiia Yu. Gazizova 2 , Igor V. Buzaev 1 ,
Irina E. Nikolaeva 1,2 , Irina A. Lakman 3 , Haibo Jia 4 , Tagir Aminov 1,2 ,
Elena A. Badykova 1 , and Naufal Sh. Zagidullin *
1
1 Department of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan,
Russia
2 Department of Cardiology, Republic Cardiological Centre, Ufa, Republic of Bashkortostan, Russia
3 Laboratory for the Study of Socio-Economic Problems of the Regions, Ufa University of Science
and Technology, Ufa, Republic of Bashkortostan, Russia

4 National Key Laboratory of Frigid Zone Cardiovascular Diseases, The Second Affiliated Hospital of
Harbin Medical University, Harbin, Heilongjiang, China
(This article belongs to the Special Issue: Special Issue of Global Translational Medicine in the
Fourth RCCCDT-2024)

Abstract

Coronary restenosis is a pressing challenge in cardiovascular diseases with an
annual incidence of 3 – 4%. The aim of the study was to assess the influence of
known risk factors in predicting coronary restenosis in a systematic analysis and
an original retrospective survey. In the first stage, we performed a systematic
review of restenosis risk factors using the Preferred Reporting Items for Systematic
*Corresponding author: Reviews and Meta-Analyses (PRISMA) protocol. In the second stage, we searched
Naufal Sh. Zagidullin
(znaufal@mail.ru) for the restenosis risk factors in 15,000 patients who had undergone coronary
angiography, considering risk factors identified during the first stage. From the
Citation: Enikeeva AM,
Gazizova LY, Buzaev IV, et al. second stage, we identified 516 patients with restenosis versus 282 patients without
Prediction of in-stent restenosis restenosis. Coronary risk factors included male sex (hazard ratio [HR] = 2.194;
based on systematic and confidence interval [CI]: 1.5 – 3.22) and history of myocardial infarction (HR = 1.098;
retrospective analyses. Global
Transl Med. 2024:3(4):4957. CI: 1.05 – 1.15). Moderate-diameter stenosis (2.75 – 3.5 mm) exhibited a protective
doi: 10.36922/gtm.4957 effect on restenosis (HR = 0.713; CI: 0.58 – 0.87), whereas small-diameter stenosis did
Received: September 26, 2024 not. Drug-eluting stents reduced the risk of restenosis (HR = 0.554; CI: 0.41 – 0.75).
The risk factors for coronary restenosis included male sex, history of myocardial
Accepted: November 22, 2024 infarction, small-diameter stent, and the use of bare-metal stents.
Published Online: December 26,
2024
Keywords: Coronary heart disease; Coronary restenosis; Risk factors; Drug-eluting stent;
Copyright: © 2024 Author(s). Bare metal stent
This is an Open-Access article
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium, 1. Introduction
provided the original work is
properly cited. Annually, cardiovascular diseases (CVD) claim millions of lives worldwide and have
1
Publisher’s Note: AccScience remained the leading cause of mortality for decades. In Europe, over 60 million potential
Publishing remains neutral with years of life are lost annually due to CVD. According to the Russian Statistical Yearbook
2
regard to jurisdictional claims in 3
published maps and institutional 2021, almost half of all deaths result from CVD, with over 80% of them being caused by
affiliations. coronary heart disease (CHD). The number of CVD-related deaths per total population
Volume 3 Issue 4 (2024) 1 doi: 10.36922/gtm.4957