Page 145 - GTM-4-1

Global Translational Medicine Weight control management during healthy aging

as reducing stress, a balanced diet and regular exercise can healthy nutrition approach to metabolic health and weight
positively contribute to the healthy aging process. In the control management, as well as physical activity habits,
4,5
medical world, it is apparent that there is an increasing contributes to the improvement of a person’s metabolic
effort in delaying the aging process by promoting a healthy health problems. 21,22
life. 6,7
2. Materials and methods
Recently, there has been a growing interest in clinical
studies on the effects of healthy lifestyle habits on healthy A detailed literature search was conducted using various
aging. These studies aim to provide further insight into databases, including the US National Library of Medicine
the role of maintaining metabolic health in maintaining (PubMed), Scopus, MEDLINE, Embase, Web of Science,
healthy aging. Evidence from these studies suggests that and SportDiscus. To gain a comprehensive understanding
dietary habits and physical activity, which are among of the subject matter, several keywords were selected for
the leading weight control methods, may play important inclusion in the search strategy, including “metabolic
roles in maintaining metabolic health during the aging health,” “longevity,” “weight control management,”
process. This has led to valuable insights into the complex “systemic healthy aging,” and “obesity.” The studies
relationship among metabolic health and individual included in the reference lists of articles identified through
quality of life, longevity, and public health policy. These the literature review were also examined, resulting in
8,9
studies aim to shed light on the intricate relationships the compilation of more exhaustive literature on the
between genetic, environmental, and behavioral factors subject matter. The search criteria were narrowed down
that influence metabolic health and overall quality of to peer-reviewed articles published in English between
10
life. In addition, there is a growing recognition of the 2004 and 2024 to focus on the results. To gain a detailed
potential benefits of personalized medicine, which seeks to understanding of the relationship among metabolic health,
develop tailored interventions based on individual genetic obesity, longevity, and various systemic conditions of
profiles and lifestyle factors to enhance the healthy aging human physiology, studies involving animal models were
process. 11,12 excluded from the search. For a study to be included in
A growing line of evidence has shown that metabolic this review, it had to meet certain criteria. First, a study
health covers a broad concept encompassing a range of had to examine the relationship between weight control
physiological processes, including glucose metabolism, lipid management and general healthy aging. Second, a study
metabolism, and energy balance. It is widely acknowledged had to be published in a peer-reviewed journal. Third,
that these processes, which are also influenced by genetic a study had to be available in English. Following a
interactions, play a pivotal role in maintaining overall comprehensive review process, a total of 44 studies were
metabolic health, preventing chronic diseases, and included in this review.
ensuring healthy aging. Studies shown that healthy and 3. Results and discussion
13
natural eating habits such as the Mediterranean diet, which
forms the basis of effective weight control strategies, may There is a consensus that maintaining a healthy weight
play a role in reducing the risk of metabolic disorders such is important for a long and quality life in elderly patients
as type 2 diabetes, cardiovascular diseases, and metabolic and effective weight control management is known to
syndrome. Based on these findings, it is useful to consider be critical for quality of life and healthy aging. Recent
a holistic approach to weight management, 14-16 as these clinical studies conducted primarily among middle-aged
important health contributions may support both the and elderly populations have suggested an increased risk
effectiveness of weight control methods and metabolic of death from cardiovascular disease, which potentially
health and hence, healthy aging. 17,18 impact the healthy aging process associated with being
overweight or obesity. It would be beneficial to highlight
Clinical research in this area aims to gain a deeper
understanding of the complex nature of metabolic health these scientific studies as they illustrate the potential
advantages of a healthy diet and weight management for
and its broader implications for public health policy. This optimal cardiovascular health and quality of life. 23,24
understanding provides insight into how factors such
as genetics, environment, and behavior, may potentially Several studies have indicated the possibility that general
influence metabolic health, longevity, and quality of dietary patterns may offer benefits for cardiovascular
life. 19,20 It is known that weight control methods that health, though further research is needed to confirm this
are supplemented with healthy nutrition can assist in postulation. Other studies have indicated that a diet rich
supporting some physiological processes which contribute in plant-based foods may have beneficial effects against
to better metabolic health. Therefore, it is thought that a the risk of developing cardiovascular disease and diabetes.

Volume 4 Issue 1 (2025) 137 doi: 10.36922/gtm.4815