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International Journal of AI
for Material and Design MMDB: A comprehensive biofabrication database

experimental design in biofabrication. Figure 6 illustrates shared knowledge, thereby accelerating scientific discovery
the detailed content of the knowledge graph. and propelling advancements in organ biofabrication.
4. Discussion Acknowledgments

The establishment of MMDB addresses a pressing need for We would like to thank Prof. Zhen Meng of the Computer
a central knowledge resource in the field of biofabrication. Network Information Center and Mr. Kai Li of the
By offering an efficient, user-friendly platform for data Institute of Zoology for their technical support in database
interaction and extraction, MMDB is poised to become a management, framework development, and data quality
vital tool in the domain of organ biofabrication. assurance.
The “Organs” section of MMDB integrates numerous Funding
biofabrication papers across an array of human organs,
constructing a comprehensive data resource. This feature This research is supported by the Strategic Priority
assists researchers in identifying the most commonly used Research Program of the Chinese Academy of Sciences
cells, biomaterials, and manufacturing strategies for various (XDA16020802), National Natural Science Foundation
organs. Moreover, it provides knowledge services, including of China (T2222029,U21A20396,62127811 and
the analysis of research hotspots, trends, and collaborations 82004050), CAS Project for Young Scientists in Basic
in the biofabrication field, as well as the creation of a Research (YSBR-012), CAS Pioneer Hundred Talents
knowledge graph to evaluate organ functions. With this Program (Y829F11102), CAS Engineering Laboratory
comprehensive collation of information, MMDB is well- for Intelligent Organ Manufacturing (KFJ-PTXM-039),
equipped to bridge current knowledge gaps and promote Incubation Foundation of Beijing Institute for Stem Cell
an environment of shared expertise within the research and Regenerative Medicine (2022FH105, 2022FH109,
community. It should be noted that the knowledge mapping 2022FH125, 2022FH210, 2022FH213, 2023FH122) and
component in the current version of MMDB is limited to China Postdoctoral Science Foundation (2022M710903).
the assessment of liver functions. However, ongoing efforts
aim to extend this feature, providing more comprehensive Conflict of interest
knowledge graphs for an increased range of organs. The authors declare that they have no competing interests.
The “Models” section of MMDB aims to predict
optimal printing parameters and organ function Author contributions
indicators. By offering such predictive analytics, the tool Conceptualization: Qi Gu, Shuyu Zhang, Jingmin An
guides researchers in their experiment design and aids in Data curation: Jingmin An, Juan Wu, Haolin Chen, Na Li
refining biofabrication methodologies. This feature holds Formal analysis: Jingmin An, Wenjuan Cui, Yishuang
significant potential to expedite progress within the field, Liang, Na Li
pushing the boundaries of what is currently achievable. Methodology: Jingmin An, Shuyu Zhang, Haolin Chen, Yi
Given that the data for model fitting are manually extracted Du
from papers, a labor-intensive process, the current version Supervision: Yi Du, Qi Gu
of MMDB solely provides liver models for function index Visualization: Jingmin An, Wenjuan Cui, Yishuang Liang
prediction. Efforts will be dedicated to refining the second Writing – original draft: Jingmin An, Wenjuan Cui
model, making it applicable to a wider range of human Writing – review and editing: Shuyu Zhang, Qi Gu
organs, and ensuring the availability of the first model. Ethics approval and consent to participate
The “Materials” section of MMDB provides a complete
knowledge graph of biomaterials and their respective Not applicable.
functions. This meticulous compilation offers researchers Consent for publication
a broad spectrum of materials to consider when planning
their experiments. It also serves as an invaluable tool for Not applicable.
identifying usage trends across different organ systems,
potentially driving innovations in materials science. Availability of data
The MMDB is available at http://data.iscr.ac.cn/mmdb.
5. Conclusion
MMDB presents a dynamic and resource-rich platform that References
addresses several challenges within the field of biofabrication. 1. Mironov V, Boland T, Trusk T, Forgacs G, Markwald RR.
It fosters an environment of collaborative learning and Organ printing: Computer-aided jet-based 3D tissue

Volume 1 Issue 1 (2024) 85 https://doi.org/10.36922/ijamd.2420