Page 305 - IJB-10-4

International

Journal of Bioprinting

RESEARCH ARTICLE
Treatment effects of 3D-printed PCL/Fe O @
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ZIF-8 magnetic nanocomposite on infected
bone defect

Yun Xiao 1,2† , Yi Ding , Jun Qiu , Xiaonan Zhang , Yanzhen Zheng ,
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3†
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Chong Huang , Lu Zhao , Zihao Tang , Yuanli Chen , Yiwen Liu ,
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Kezhen Zhao , Kai Guo , Li Jing , Mingchao Ding , Chunlin Zong *,
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Jiankang He *, and Lei Tian *
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1 School of Stomatology, Jiamusi University, Jiamusi, Heilongjiang, China
2 State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical
Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department
of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University,
Xi’an, Shaanxi, China
3 State Key Laboratory for Manufacturing Systems Engineering, National Medical Products
Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing
Medical Devices, Xi’an Jiaotong University, Xi’an, Shaanxi, China
4 State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical
Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of
Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical
University, Xi’an, Shaanxi, China
5 Frontier Institute of Science and Technology (FIST), State Key Laboratory of Mechanical Behavior
† These authors contributed equally for Materials, MOE Key Laboratory for Nonequilibrium Synthesis of Condensed Matter, Xi’an Key
to this work. Laboratory of Sustainable Energy and Materials Chemistry, School of Chemistry, Xi’an Jiaotong
University, Xi’an, Shaanxi, China
*Corresponding authors:
Lei Tian (tianleison@163.com)
Jiankang He
(jiankanghe@mail.xjtu.edu.cn) Abstract
Chunlin Zong
(mujiezi23@163.com)
Treatment of large bone defects remains a clinical challenge, especially for defects
Citation: Xiao Y, Ding Y, Qiu J, compounded by infection. It is essential to develop dual functional therapeutic
et al. Treatment effects of systems that inhibit bacterial growth and promote bone regeneration for infected
3D-printed PCL/Fe3O4@ZIF-8
magnetic nanocomposite on bone defects treatment. However, the ideal bone substitute biomaterials to repair
infected bone defect. infected bone defects remain scarce. In this study, we fabricated a novel magnetic
Int J Bioprint. 2024;10(4):2271. nanocomposite with polycaprolactone (PCL)/Fe O @zinc-based imidazole zeolite
doi: 10.36922/ijb.2271 3 4
framework-8 (ZIF-8) through three-dimensional (3D) printing technology. The
Received: November 17, 2023 biomaterial characterization, biocompatibility, antibacterial activity, and osteogenic
Accepted: February 5, 2024
Published Online: March 27, 2024 ability of the 3D-printed PCL/Fe O @ZIF-8 nanocomposite were systematically
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investigated in vivo and in vitro. The 3D-printed PCL/Fe O @ZIF-8 nanocomposite
Copyright: © 2024 Author(s). 3 4
This is an Open Access article scaffolds showed a square porous grid structure with rough surface, thermal stability,
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distributed under the terms of the superparamagnetic character, and slow release of Zn . The elevation of Fe O @ZIF-8
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Creative Commons Attribution concentration increased surface roughness and porosity, improved the mechanical
License, permitting distribution,
and reproduction in any medium, properties, and enhanced the saturation magnetization of PCL/Fe O @ZIF-8 scaffolds.
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provided the original work is The PCL/Fe O @ZIF-8 scaffolds possessed good biocompatibility and promoted the
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properly cited. proliferation and adhesion of rat bone marrow mesenchymal stem cells (BMSCs).
Publisher’s Note: AccScience The PCL/Fe O @ZIF-8 scaffolds also upregulated the expression of osteogenic-
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Publishing remains neutral with related genes and proteins and promoted the osteogenic differentiation of BMSCs
regard to jurisdictional claims in by activating the Wnt/β-catenin signaling pathway. Furthermore, the scaffolds
published maps and institutional
affiliations. showed excellent antibacterial activities, which increased with increasing Fe O @
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Volume 10 Issue 4 (2024) 297 doi: 10.36922/ijb.2271