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International Journal of Bioprinting 3D-printing silicone patient-specific soft-tissue expander

expander were validated through patient-specific cases, Consent for publication
involving extensive left/right mandibular bone defects.
Additionally, FE analysis confirmed that the stress on the Not applicable.
soft tissue remained within safe limits during expansion. Availability of data
However, the findings of this study would warrant further
validation with in vivo animal testing before considering Data are available from the corresponding author upon
the clinical application of the novel silicone expanders. reasonable request.

5. Conclusion References

This study utilized biocompatible Carbopol 940 polymer to 1. Bassetti RG, Stähli A, Bassetti M, et al. Soft tissue
create swellable tablets and employed silicone 3D-printing augmentation procedures at second-stage surgery: a
technology to fabricate a silicone membrane enveloping the systematic review. Clin Oral Investig. 2016;20(7):1369-1387.
tablets with specific shapes to generate a novel soft-tissue doi: 10.1007/s00784-016-1815-2
expander. The relationship between the expansion volume
and time of the novel silicone expander followed a fourth- 2. Razzak MA, Hossain MS, Radzi ZB, et al. Cellular and
molecular responses to mechanical expansion of tissue.
degree polynomial, with slower expansion rates during the Front Physiol. 2016;15(7):540.
initial 2 weeks to safeguard the soft tissue. Patient-specific doi: 10.3389/fphys.2016.00540
silicone expanders were produced based on actual clinical
cases, involving large left and right mandibular bone 3. Gade Ellesøe A, Shado R, Pereira IN, et al. Soft tissue
defects and subjected to a 6-week expansion test in vitro. expansion using self-inflating osmotic hydrogel expanders
The results validated the feasibility of the silicone expander prior to bone augmentation: healing and complications.
Evidence-based review. BDJ Open. 2023;9(1):48.
with a volume expansion error of less than 2%.
doi: 10.1038/s41405-023-00175-3
Acknowledgments 4. Byun SH, Kim SY, Lee H, et al. Soft tissue expander
for vertically atrophied alveolar ridges: Prospective,
None. multicenter, randomized controlled trial. Clin Oral Implants
Res. 2020;31(7):585-594.
Funding doi: 10.1111/clr.13595
This study was supported in part by the Ministry of Science 5. Jaksa L, Aryeetey OJ, Hatamikia S, et al. 3D-Printed multi-
and Technology (MOST; Project numbers: 108-2622-E-010- material liver model with simultaneous mechanical and
001-CC2 and 110-2222-E-032-003-MY2), Taiwan. radiological tissue-mimicking features for improved realism.
Int J Bioprint. 2023;9(4):721.
Conflict of interest doi: 10.18063/ijb.721
6. Chow L, Yick KL, Kwan MY, et al. Customized fabrication
The authors declare no conflicts of interest.
approach for hypertrophic scar treatment: 3D printed fabric
silicone composite. Int J Bioprint. 2020;6(2):262.
Author contributions doi: 10.18063/ijb.v6i2.262
Conceptualization: Tzu-Huan Huang, Chun-Liang Lo, 7. Uijlenbroek HJJ, Liu Y, Wismeijer D. Soft tissue expansion:
Chun-Li Lin principles and inferred intraoral hydrogel tissue expanders.
Formal analysis: Shao-Fu Huang, Lu-Yi Yu, Yu-Ping Chang Dent Oral Craniofac Res. 2015;10:15761.
Investigation: Shao-Fu Huang, Lu-Yi Yu, Yu-Ping Chang doi: 10.15761/DOCR.1000140
Chun-Li Lin 8. Aslani A, Malekpour N. Design, formulation, and
Methodology: Shao-Fu Huang, Lu-Yi Yu, Yu-Ping Chang physicochemical evaluation of periodontal propolis
Writing – original draft: Tzu-Huan Huang, Chun-Liang mucoadhesive gel. Dent Res J. 2016;13(6):484-493.
Lo, Chun-Li Lin doi: 10.4103/1735-3327.197037
Writing – review & editing: Chun-Li Lin
9. ISO 10993-5:2009. Biological evaluation of medical devices
Ethics approval and consent to participate — Part 5: tests for in vitro cytotoxicity.
10. Imoto K, Yamauchi K, Odashima K, et al. Periosteal
This study was approved by the Institutional Review Board expansion osteogenesis using an innovative, shape-memory
(IRB) of Taipei Mackay Memorial Hospital (Protocol polyethylene terephthalate membrane: an experimental
title: Morphological Study of Mandibular Defects; IRB study in rabbits. J Biomed Mater Res B Appl Biomater.
number: 23MMHIS238e). 2021;109(9):1327-1333.

Volume 10 Issue 4 (2024) 579 doi: 10.36922/ijb.2918