Page 136 - IJB-7-1
P. 136

Actualizing Hybrid Pressure and Silicone Therapies with 3D Printing and Scanning
           silicone sheet and scar treating gel is not recommended   References
           for treatment of HSs. Instead, we propose a novel
           bespoke HS treatment involving a combination of 3D   1.   Ogawa R, 2020, Total Scar Management : From Lasers to
           scanning, 3D printing, FEA, computer-aided design,      Surgery for Scars, Keloids, and Scar Contractures. Springer,
           and manufacturing software.  The 3D printed silicone    Singapore.
           elastomer that only covers the HS itself is secured to      https://doi.org/10.1007/978-981-32-9791-3
           a bespoke pressure sleeve. Since the silicone sheet is   2.   Tredget EE, Nedelec B, Scott PG, et al., 1997, Hypertrophic
           secured by the pressure from the sleeve, any type of scar   Scars, Keloids, and Contractures: The Cellular and Molecular
           treating gel can be applied at the same time. Using an   Basis for Therapy. Surg Clin North Am, 77(3):701–30.
           FEA, the pressure dosage for the HS can be accurately
           modified, which in this case, is approximately 25 mmHg      https://doi.org/10.1016/s0039-6109(05)70576-4
           for the effective management of HS. Most importantly,   3.   Grose  R,  Werner  S, 2004,  Wound-healing  Studies  in
           the unnecessary pressure exerted on normal skin can be   Transgenic and Knockout Mice.  Appl Biochem Biotechnol
           reduced by approximately 60%, 56%, and 80% at the       Part B Mol Biotechnol, 28(2):147–66.
           ulnar, radial, and back of the hand, respectively. In this      https://doi.org/10.1385/mb:28:2:147
           case study, the suggested treatment provides a significant   4.   Son D, Harijan A, 2014, Overview of Surgical Scar Prevention
           effect in reducing the scar thickness and pigmentation.   and Management. J Korean Med Sci, 29(6):751–7.
           Also, there is no adverse effects of the hybrid pressure
           and silicone therapy found.  The developed design       https://doi.org/10.3346/jkms.2014.29.6.751
           framework and production of the pressure garment can   5.   Enoch S, Leaper DJ, 2008, Basic Science of Wound Healing.
           contribute to new insights for future HS therapies and   Surgery (Oxford), 26(2):31–7.
           new customized clinical products for scars.             https://doi.org/10.1016/j.mpsur.2007.11.005
                                                               6.   Werner S, Krieg T, Smola H, 2007, Keratinocyte-fibroblast
           Acknowledgments
                                                                   Interactions  in  Wound Healing.  J Investig  Dermatol,
           We  acknowledge  the  financial  support  of  the  Research   127(5):998–1008.
           Grant Council for funding this research project (project      https://doi.org/10.1038/sj.jid.5700786
           account PolyU 152097/18E).                          7.   Nagase H,  Woessner JF, 1999, Matrix Metalloproteinases.
           Conflicts of interest                                   J Biol Chem, 274(31):21491–4.
                                                                   https://doi.org/10.1074/jbc.274.31.21491
           The authors report no potential conflicts of interest.
                                                               8.   Bock O, Schmid-Ott G, Malewski P, et al., 2006, Quality of
           Author contribution                                     Life of Patients with Keloid and Hypertrophic Scarring. Arch
                                                                   Dermatol Res, 297(10):433–8.
           L.C. designed the workflow, methodology, data curation      https://doi.org/10.1007/s00403-006-0651-7
           and  prepared  the  original  draft  of the  manuscript  and
           figures.  Co-authors Y.S.,  M.S.H.L  and  M.Y.K  involved   9.   Mazharinia N, Aghaei S, Shayan Z, 2007, Dermatology life
           in the investigation  and analysis of results. K.L.Y.   quality  index  (DLQI) scores  in  burn  victims  after  revival.
           supervised and administered the project. K.L.Y., S.P.N,   J Burn Care Res, 28(2):312–7.
           A.Y., J.Y. and Y.F.C. acquired the project funding, and      https://doi.org/10.1097/bcr.0b013e318031a151
           reviewed and edited the manuscript.                 10.  Kwan P, Hori K, Ding J, et al., 2009, Scar and Contracture:

           Ethics approval and consent to participate              Biological Principles. Hand Clin, 25(4):511–28.
                                                                   https://doi.org/10.1016/j.hcl.2009.06.007
           This study was approved  by the  Human Subjects     11.  van  Vlimmeren MA,  Driessen-Mol A,  van Den Broek M,
           Ethics  Sub-committee  of  The Hong Kong Polytechnic    et  al., 2010, Controlling matrix formation and cross-linking
           University and Joint Chinese University of Hong Kong-   by hypoxia  in  cardiovascular  tissue  engineering.  J  Appl
           New  Territories  East  Cluster  Clinical  Research  Ethics
           Committee. Written informed consent was obtained from   Physiol (Bethesda, Md. 1985), 109(5):1483.
           the participant before data collection.                 https://doi.org/10.1152/japplphysiol.00571.2010
                                                               12.  Teekakirikul P, Eminaga S,  Toka O, et al., 2010, Cardiac
           Consent for publication                                 Fibrosis in Mice with Hypertrophic Cardiomyopathy  is

           The patient provided written informed consent to publish   Mediated by Non-myocyte Proliferation and Requires Tgf-
           the pictures and her personal data.                     [Beta]. J Clin Investig, 120(10):3520–9.

           132                         International Journal of Bioprinting (2021)–Volume 7, Issue 1
   131   132   133   134   135   136   137   138   139   140   141