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Rodriguez-Salvador, et al.
A B

C D

Figure 5. Global scientific trends in tissue spheroids as building blocks in the Seeding category. A summary of the publications that
are indexed in Scopus according to (A) the ten most frequent countries and (B) cities of the authors; (C) the ten journals with the most
occurrences of the searched terms; and (D) the ten most frequent organizational affiliations of the authors.

A B

Figure 6. Global scientific trends in tissue spheroids as building blocks in the Biofabrication category. A summary of the publications that
are indexed in Scopus according to (A) the ten most frequent countries and (B) cities of the authors.

acute-on-chronic liver failure: A randomized controlled other hand, the top-cited article in the Biofabrication
trial , where the use of mesenchymal stromal cells category was Accessible bioprinting: Adaptation of a
[22]
(MSCs) to decrease mortality in hepatitis B virus-related low-cost 3D-printer for precise cell placement and stem
acute-on-chronic liver failure was studied. Followed by cell differentiation , cited 60 times. The article laid
[25]
3D spheroid culture enhances survival and therapeutic out an accessible 3D bioprinter capable of printing and
capacities of MSCs injected into ischemic kidney , differentiating human induced pluripotent stem cells
[23]
the second most cited article overall and in the Seeding (hiPSC) into Gletrex. With 58 citations Towards Single-
category with 91 citations. This publication investigates Step Biofabrication of Organs on a Chip via 3D Printing
[26]
the in vitro therapeutic effects of 3D spheroids of human/ is the second most cited article. It is a review where organ-
adipose MSCs in the treatment of acute kidney injury on-a-chip engineering applies microfabrication of living
(AKI). The third most cited article overall, also in the tissue with microscale fluid that mimics human organs
Seeding category, was Combined intramyocardial with 3D printing. The third most cited article was Airflow-
delivery of human pericytes and cardiac stem cells Assisted 3D Bioprinting of Human Heterogeneous
additively improves the healing of mouse infarcted hearts Microspheroidal Organoids with Microfluidic Nozzle ,
[27]
through stimulation of vascular and muscular repair , with 51 citations. The study presents a contemporary
[24]
with 88 citations. In this article, the use of saphenous airflow-assisted 3D bioprinting method that creates spiral
vein-derived pericytes and cardiac stem cells as a repair microarchitectures inside the microspheroids to achieve
tool in myocardial infarction was analyzed. On the heterogeneous tissue spheroids.

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