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International

Journal of Bioprinting

EDITORIAL
Bioprinting for tissue engineering and modeling

Xiongbiao Chen 1 id and Liqun Ning 2 id

1 Department of Mechanical Engineering, College of Engineering, University of Saskatchewan,
Saskatoon, Saskatchewan, Canada
2 Department of Mechanical Engineering, Washkewicz College of Engineering, Cleveland State
University, Cleveland, Ohio, USA
(This editorial belongs to the Special Issue: Bioprinting for Tissue Engineering and Modeling)

Bioprinting has emerged as a transformative technology in tissue engineering and
regenerative medicine, enabling the precise spatial arrangement of cells, biomaterials,
and bioactive molecules to fabricate complex, functional tissue constructs. This Special
Issue of the International Journal of Bioprinting, titled “Bioprinting for Tissue Engineering
and Modeling,” presents six original research articles that exemplify the diversity and
innovation in this rapidly evolving field. These contributions span applications in ocular
drug delivery, bone regeneration, respiratory disease modeling, pluripotent stem cell
expansion, bioink optimization, and multi-material printing strategies.

In the first article, Khoshnood et al. developed a 3D-bioprinted gellan gum–
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polyethyleneimine (GG–PEI) hydrogel system loaded with betamethasone for ocular
drug delivery. The constructs demonstrated favorable mechanical properties, high
transparency, and sustained drug release, making them suitable for treating ocular
inflammation. This study highlights the potential of bioprinting in creating personalized,
site-specific drug delivery systems.
Kühl et al. investigated the incorporation of nanosilicates into gelatin methacryloyl
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(GelMA) bioinks for digital light processing (DLP)-based bioprinting of bone constructs.
Their findings revealed enhanced mechanical strength and improved mesenchymal
stem cell (MSC) proliferation and osteogenic differentiation. This work underscores
the importance of nanomaterial-enhanced bioinks in improving the structural and
biological performance of bioprinted bone scaffolds.
Citation: Chen X, Ning L.
Bioprinting for tissue engineering Zimmerling et al. presented a 3D-bioprinted respiratory disease model that
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and modeling.
Int J Bioprint. 2025;11(4):1-3. simulates infection dynamics under various culture conditions. The model incorporates
doi: 10.36922/IJB025300302 human bronchial epithelial cells and mimics the airway microenvironment,
Received: July 23, 2025 offering a valuable platform for studying host–pathogen interactions and evaluating
Published online: August 20, therapeutic interventions. The study emphasizes the role of controlled release and
2025 microenvironmental factors in replicating disease progression.
Copyright: © 2025 Author(s). Komosa et al. addressed the challenge of pluripotent stem cell (PSC) expansion by
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This is an Open Access article
distributed under the terms of the developing a GelMA-based bioprinted construct that supports robust and reproducible
Creative Commons Attribution PSC growth. The study systematically evaluates the influence of construct geometry,
License, permitting distribution, stiffness, and culture conditions on PSC proliferation and pluripotency maintenance.
and reproduction in any medium,
provided the original work is This work contributes to the development of scalable platforms for stem cell expansion
properly cited. and differentiation.
Publisher’s Note: AccScience Lim et al. optimized a composite bioink composed of alginate, gelatin, and dextran-
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Publishing remains neutral with
regard to jurisdictional claims in aldehyde for 3D bioprinting and cell engraftment. The study demonstrates that the
published maps and institutional optimized formulation supports high cell viability, print fidelity, and tissue integration.
affiliations.

Volume 11 Issue 4 (2025) 1 doi: 10.36922/IJB025300302