Page 42 - IMO-2-1

Innovative Medicines & Omics

REVIEW ARTICLE
Innovative approaches in kidney disease

management: Advances in therapeutics and
treatment strategies

1
Suchismita Roy * , Palash Mitra 1,2 , Sahadeb Jana 1,2 , Kaberi Kandar 2,3 ,
and Malay Kumar Patsa 1
1 Nutrition Research Laboratory, Department of Paramedical Allied Health Sciences, Midnapore City
College, Midnapore, West Bengal, India
2 Biodiversity and Environmental Studies Research Centre, Midnapore City College Affiliated to
Vidyasagar University, Midnapore, West Bengal, India
3 Department of Nutrition, Bajkul Milani Mahavidyalaya, Purba Medinipur West Bengal, India

Abstract

The health system is burdened by kidney disease (KD), which has considerable
economic consequences. The aging population and the rise in Type 2 diabetes
and hypertension are the main contributing causes. KD is also associated with an
increased risk of cardiovascular diseases (CVDs) morbidity, early mortality, and
reduced quality of life. Recent studies estimate that more than 850 million people
worldwide are affected by kidney-related illnesses each year. Of these, about 3.9
*Corresponding author: million individuals are going through dialysis or kidney transplantations, neither of
Suchismita Roy which provides an ultimate solution. Alternative therapeutic approaches through
(suchismitaroy@mcconline.org.in)
medications include the use of angiotensin-converting enzyme inhibitors and
Citation: Roy S, Mitra P, Jana S, Angiotensin II receptor blockers, renin inhibitors, anti-inflammatory medicines, and
Kandar K, Patsa MK. Innovative
approaches in kidney disease bioactive phytocompounds isolated from several plants. Plants contain numerous
management: Advances in bioactive compounds that are thought to provide a variety of health benefits,
therapeutics and treatment including potential nephroprotective properties. In this review, recent advancements
strategies. Innov Med Omics.
2025;2(1):36-49. in kidney disease (KD) research will be highlighted, including newly identified causes,
doi: 10.36922/imo.4969 renal pathophysiological alterations, and current therapeutic approaches.
Received: September 26, 2024
1st revised: November 20, 2024 Keywords: Kidney disease; Phytocompounds; Nephroprotective; Anti-inflammatory
2nd revised: December 12, 2024
3rd revised: December 16, 2024
Accepted: December 24, 2024
Published online: January 20,
2025 1. Introduction
Copyright: © 2025 Author(s).
This is an Open-Access article Acute kidney injury (AKI) is a syndrome characterized by reduced urine production and
distributed under the terms of the the accumulation of nitrogen metabolism end products, such as urea and creatinine in
Creative Commons Attribution renal tubules. At the initial phase of injury and inflammation, circulating immune cells
1
License, permitting distribution,
and reproduction in any medium, (T- and B-cells) infiltrate the kidney, drawn in by cytokines, chemokines, and damage-
provided the original work is associated molecular patterns (DAMPs) generated by wounded cells. DAMPs contribute
properly cited. to a pro-fibrotic environment by interacting with activated monocytes/macrophages,
Publisher’s Note: AccScience damaged tubular epithelial cells (TECs), and endothelial cells. This environment
Publishing remains neutral with stimulates pericytes to proliferate and differentiate into myofibroblasts, which causes
regard to jurisdictional claims in
published maps and institutional extracellular matrix (ECM) protein deposition, renal fibrosis, and progression to
affiliations. chronic kidney disease (CKD). TECs may have a pro-fibrotic phenotype and become

Volume 2 Issue 1 (2025) 36 doi: 10.36922/imo.4969