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Innovative Medicines & Omics Tyrosine kinases: Structure, mechanism, and therapeutics

doi: 10.3389/fonc.2023.1258371 doi: 10.1073/pnas.87.21.8602
108. Martin-Fernandez ML, Clarke DT, Roberts SK, Zanetti- 119. Reynolds AB, Roczniak-Ferguson A. Emerging roles
Domingues LC, Gervasio FL. Structure and dynamics of the for p120-catenin in cell adhesion and cancer. Oncogene.
EGF receptor as revealed by experiments and simulations and 2004;23(48):7947-7956.
its relevance to non-small cell lung cancer. Cells. 2019;8(4):316.
doi: 10.1038/sj.onc.1208161
doi: 10.3390/cells8040316
120. Summy JM, Gallick GE. Src family kinases in tumor
109. Shigematsu H, Gazdar AF. Somatic mutations of epidermal progression and metastasis. Cancer Metastasis Rev.
growth factor receptor signaling pathway in lung cancers. 2003;22(4):337-358.
Int J Cancer. 2006;118(2):257-262.
doi: 10.1023/a:1023772912750
doi: 10.1002/ijc.21496
121. Silva CM. Role of STATs as downstream signal transducers
110. Tatematsu A, Shimizu J, Murakami Y, et al. Epidermal in Src family kinase-mediated tumorigenesis. Oncogene.
growth factor receptor mutations in small cell lung cancer. 2004;23(48):8017-8023.
Clin Cancer Res. 2008;14(19):6092-6096.
doi: 10.1038/sj.onc.1208159
doi: 10.1158/1078-0432.Ccr-08-0332
122. Dong YL, Vadla GP, Lu JJ, et al. Cooperation between
111. Doss GP, Rajith B, Chakraborty C, NagaSundaram N, Ali SK, oncogenic Ras and wild-type p53 stimulates STAT non-cell
Zhu H. Structural signature of the G719S-T790M double autonomously to promote tumor radioresistance. Commun
mutation in the EGFR kinase domain and its response to Biol. 2021;4(1):374.
inhibitors. Sci Rep. 2014;4:5868.
doi: 10.1038/s42003-021-01898-5
doi: 10.1038/srep05868
123. Delgado L, Monteiro L, Silva P, et al. BUBR1 as a prognostic
112. Sigismund S, Avanzato D, Lanzetti L. Emerging functions of biomarker in canine oral squamous cell carcinoma. Animals
the EGFR in cancer. Mol Oncol. 2018;12(1):3-20. (Basel). 2022;12(22):3082.
doi: 10.1002/1878-0261.12155 doi: 10.3390/ani12223082
113. Tan X, Lambert PF, Rapraeger AC, Anderson RA. Stress- 124. Tokumitsu Y, Nakano S, Ueno H, Niho Y. Suppression of
induced EGFR trafficking: Mechanisms, functions, and malignant growth potentials of v-Src-transformed human
therapeutic implications. Trends Cell Biol. 2016;26(5):352-366. gallbladder epithelial cells by adenovirus-mediated dominant
doi: 10.1016/j.tcb.2015.12.006 negative H-Ras. J Cell Physiol. 2000;183(2):221-227.
114. Jutten B, Keulers TG, Schaaf MB, et al. EGFR overexpressing doi: 10.1002/(sici)1097-4652(200005)183:2<221:Aid-
cells and tumors are dependent on autophagy for growth jcp8>3.0.Co;2-l
and survival. Radiother Oncol. 2013;108(3):479-483. 125. Jaber Chehayeb R, Stiegler AL, Boggon TJ. Crystal structures
doi: 10.1016/j.radonc.2013.06.033 of p120RasGAP N-terminal SH2 domain in its apo form and
in complex with a p190RhoGAP phosphotyrosine peptide.
115. Casanova ML, Larcher F, Casanova B, et al. A critical role for PLoS One. 2020;14(12):e0226113.
ras-mediated, epidermal growth factor receptor-dependent
angiogenesis in mouse skin carcinogenesis. Cancer Res. doi: 10.1371/journal.pone.0226113
2002;62(12):3402-3407. 126. Biscardi JS, Tice DA, Parsons SJ. c-Src, receptor tyrosine
116. Ekstrand AJ, Sugawa N, James CD, Collins VP. Amplified kinases, and human cancer. Adv Cancer Res. 1999;76:61-119.
and rearranged epidermal growth factor receptor genes doi: 10.1016/s0065-230x(08)60774-5
in human glioblastomas reveal deletions of sequences
encoding portions of the N- and/or C-terminal tails. Proc 127. Ingley E. Src family kinases: Regulation of their activities,
Natl Acad Sci U S A. 1992;89(10):4309-4313. levels and identification of new pathways. Biochim Biophys
Acta. 2008;1784(1):56-65.
doi: 10.1073/pnas.89.10.4309
doi: 10.1016/j.bbapap.2007.08.012
117. Wong AJ, Ruppert JM, Bigner SH, et al. Structural alterations
of the epidermal growth factor receptor gene in human 128. Zhong L, Zhao Z, Peng X, Zou J, Yang S. Recent advances
gliomas. Proc Natl Acad Sci U S A. 1992;89(7):2965-2969. in small-molecular therapeutics for COVID-19. Precis Clin
Med. 2022;5(4):pbac024.
doi: 10.1073/pnas.89.7.2965
doi: 10.1093/pcmedi/pbac024
118. Sugawa N, Ekstrand AJ, James CD, Collins VP. Identical splicing
of aberrant epidermal growth factor receptor transcripts from 129. Broekman F, Giovannetti E, Peters GJ. Tyrosine kinase
amplified rearranged genes in human glioblastomas. Proc Natl inhibitors: Multi-targeted or single-targeted? World J Clin
Acad Sci U S A. 1990;87(21):8602-8606. Oncol. 2011;2(2):80-93.

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