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Innovative Medicines & Omics Tyrosine kinases: Structure, mechanism, and therapeutics

62. Fhu CW, Ali A. Protein lipidation by palmitoylation and cancers and TRK inhibitor therapy. Nat Rev Clin Oncol.
myristoylation in cancer. Front Cell Dev Biol. 2021;9:673647. 2018;15(12):731-747.
doi: 10.3389/fcell.2021.673647 doi: 10.1038/s41571-018-0113-0
63. Kinoshita-Kikuta E, Utsumi T, Miyazaki A, et al. Protein-N- 74. Melillo RM, Santoro M. The RET receptor family. In:
myristoylation-dependent phosphorylation of serine 13 of Wheeler DL, Yarden Y, editors. Receptor Tyrosine Kinases:
tyrosine kinase Lyn by casein kinase 1γ at the Golgi during Family and Subfamilies. Berlin: Springer International
intracellular protein traffic. Sci Rep. 2020;10(1):16273. Publishing; 2015. p. 559-591.
doi: 10.1038/s41598-020-73248-0 75. Green J, Nusse R, van Amerongen R. The role of Ryk and
Ror receptor tyrosine kinases in Wnt signal transduction.
64. Berclaz G, Altermatt HJ, Rohrbach V, Dreher E, Ziemiecki A, Cold Spring Harb Perspect Biol. 2014;6(2):a009175.
Andres AC. Hormone-dependent nuclear localization of the
tyrosine kinase iyk in the normal human breast epithelium doi: 10.1101/cshperspect.a009175
and loss of expression during carcinogenesis. Int J Cancer. 76. Leitinger B. Discoidin domain receptor functions in
2000;85(6):889-894. physiological and pathological conditions. Int Rev Cell Mol
doi: 10.1002/(sici)1097-0215(20000315)85:6<889:aid- Biol. 2014;310:39-87.
ijc25>3.0.co;2-4 doi: 10.1016/b978-0-12-800180-6.00002-5
65. Gu JJ, Ryu JR, Pendergast AM. Abl tyrosine kinases in T-cell 77. Toy KA, Valiathan RR, Núñez F, et al. Tyrosine kinase
signaling. Immunol Rev. 2009;228(1):170-183. discoidin domain receptors DDR1 and DDR2 are
doi: 10.1111/j.1600-065X.2008.00751.x coordinately deregulated in triple-negative breast cancer.
Breast Cancer Res Treat. 2015;150(1):9-18.
66. Colicelli J. ABL tyrosine kinases: Evolution of function,
regulation, and specificity. Sci Signal. 2010;3(139):re6. doi: 10.1007/s10549-015-3285-7
doi: 10.1126/scisignal.3139re6 78. Della Corte CM, Viscardi G, Di Liello R, et al. Role and
targeting of anaplastic lymphoma kinase in cancer. Mol
67. Ganguly SS, Plattner R. Activation of abl family kinases in Cancer. 2018;17(1):30.
solid tumors. Genes Cancer. 2012;3(5-6):414-425.
doi: 10.1186/s12943-018-0776-2
doi: 10.1177/1947601912458586
79. Bencze J, Szarka M, Bencs V, et al. Neuropathological
68. Hobbs HT, Shah NH, Badroos JM, Gee CL, Marqusee S, characterization of Lemur tyrosine kinase 2 (LMTK2) in
Kuriyan J. Differences in the dynamics of the tandem-SH2 Alzheimer’s disease and neocortical Lewy body disease. Sci
modules of the Syk and ZAP-70 tyrosine kinases. Protein Sci. Rep. 2019;9(1):17222.
2021;30(12):2373-2384.
doi: 10.1038/s41598-019-53638-9
doi: 10.1002/pro.4199
80. Hu L, Chen HY, Cai J, et al. Serine threonine tyrosine kinase
69. Qu C, Zheng D, Li S, et al. Tyrosine kinase SYK is a 1 is a potential prognostic marker in colorectal cancer. BMC
potential therapeutic target for liver fibrosis. Hepatology. Cancer. 2015;15:246.
2018;68(3):1125-1139.
doi: 10.1186/s12885-015-1285-y
doi: 10.1002/hep.29881
81. Rajpurohit YS, Sharma DK, Misra HS. Involvement of serine/
70. Harrison PT, Vyse S, Huang PH. Rare epidermal growth threonine protein kinases in DNA damage response and cell
factor receptor (EGFR) mutations in non-small cell lung division in bacteria. Res Microbiol. 2022;173(1):103883.
cancer. Semin Cancer Biol. 2020;61:167-179.
doi: 10.1016/j.resmic.2021.103883
doi: 10.1016/j.semcancer.2019.09.015
82. Seok SH. Structural insights into protein regulation by
71. Cébe-Suarez S, Zehnder-Fjällman A, Ballmer-Hofer K. phosphorylation and substrate recognition of protein
The role of VEGF receptors in angiogenesis; complex kinases/phosphatases. Life (Basel). 2021;11(9):957.
partnerships. Cell Mol Life Sci. 2006;63(5):601-615.
doi: 10.3390/life11090957
doi: 10.1007/s00018-005-5426-3
83. Yamaoka K, Saharinen P, Pesu M, Holt VE 3 ,
rd
72. Shibuya M. Vascular endothelial growth factor (VEGF) and Silvennoinen O, O’Shea JJ. The Janus kinases (Jaks). Genome
its receptor (VEGFR) signaling in angiogenesis: A crucial Biol. 2004;5(12):253.
target for anti- and pro-angiogenic therapies. Genes Cancer. doi: 10.1186/gb-2004-5-12-253
2011;2(12):1097-1105.
84. Ivanova IA, Vermeulen JF, Ercan C, et al. FER kinase
doi: 10.1177/1947601911423031
promotes breast cancer metastasis by regulating a6- and
73. Cocco E, Scaltriti M, Drilon A. NTRK fusion-positive β1-integrin-dependent cell adhesion and anoikis resistance.

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