Page 29 - ITPS-7-1

INNOSC Theranostics

and Pharmacological Sciences

REVIEW ARTICLE
Antiplatelet, anticoagulation, and elective

aneurysm treatments in neurological patients

2
1
1
1
Anjali Patel , Daisy Valle , Drashti Patel , Marco Foreman , Akash Nijhawan ,
1
2
4
3
Devon Foster , Alexander Nguyen , and Brandon Lucke-Wold *
1 University of Florida College of Medicine, Gainesville, FL, USA
2 Florida International University Herbert Wertheim College of Medicine, Miami, FL, USA
3 Creighton University School of Medicine, Omaha, Nebraska, USA
4 Department of Neurosurgery, University of Florida, Gainesville, FL, USA
Abstract

Developing more specialized care for neurological disorders, such as aneurysms,
arteriovenous malformations, and strokes, can revolutionize patient healthcare
and outcomes. With the advent of surgical techniques such as flow diversion, non-
stent- and stent-assisted coiling, and catheter embolization for elective aneurysm
treatment in neurological patients, the adverse effects and morbidities associated
with aneurysms can be reduced. This paper aims to highlight three specific strengths
and weaknesses of the newly emerged techniques. Flow diversion devices involve
*Corresponding author: placing a stent in the parent artery, whereas Woven EndoBridge embolization involves
Brandon Lucke-Wold manipulation of the wall of the artery without the administration of dual-antiplatelet
(Brandon.Lucke-Wold@ therapy. In addition to aneurysm treatment, the administration of antiplatelets
neurosurgery.ufl.edu)
and anticoagulants is helpful in disrupting the coagulation cascade. As stated in
Citation: Patel A, Valle D, the new and enhanced guidelines released by the American Heart Association, the
Patel D, et al. 2024, Antiplatelet, administration of dual anticoagulants is beneficial to the patients if they have low
anticoagulation, and elective
aneurysm treatments in ischemic severity. Understanding the various benefits and complications associated
neurological patients. INNOSC with each treatment can allow clinicians to gain insight into the potential trajectory
Theranostics and Pharmacological of treatment for different patients.
Sciences, 7(1): 1202.
https://doi.org/10.36922/itps.1202
Received: June 29, 2023 Keywords: Aneurysm; Stent-assisted embolization; Antiplatelet therapy; Woven
Accepted: August 23, 2023 Endobridge embolization; Catheter embolization
Published Online: October 18,
2023
Copyright: © 2023 Author(s). 1. Introduction
This is an Open-Access article
distributed under the terms of the In the realm of neurosurgical care, emerging approaches have opened up new frontiers
Creative Commons Attribution and revolutionized the management of challenging neurovascular manifestations by
License, permitting distribution,
and reproduction in any medium, offering patients minimally invasive treatments that come with exceptionally promising
provided the original work is outcomes [1-3] . The field of neurovascular diseases encompasses a wide range of neurological
properly cited. disorders, such as intracranial aneurysms, acute ischemic strokes, cerebral arteriovenous
Publisher’s Note: AccScience malformations, and vascular growths, which require specialized expertise and thorough,
Publishing remains neutral with comprehensive care. For instance, cerebral aneurysms — abnormal bulges that develop
regard to jurisdictional claims in
published maps and institutional in the blood vessels of the brain — and arteriovenous malformations — tangled networks
affiliations. of abnormal blood vessels in the brain or spine — are both vascular conditions that

Volume 7 Issue 1 (2024) 1 https://doi.org/10.36922/itps.1202