Page 71 - ITPS-7-2

INNOSC Theranostics and
Pharmacological Sciences Youth brain health check and dysregulation

the general US population. This commission believes that the Writing – original draft: Kenneth Blum, Eric Braverman
BHC/BHCo would synergize with current fitness programs, Writing – review & editing: All authors
particularly in addressing co-occurring RDS behaviors.
Thanos et al. underscore the role of exercise in preventing Ethics approval and consent to participate
158
the initiation of cocaine use in adolescence, suggesting that the Not applicable.
implementation of exercise programs might be an important
preventive measure and significantly improve students’ Consent for publication
mental health. Based on the reviewed research, this appeal Not applicable.
promises to stop/prevent the increased prevalence of SUD
through early detection utilizing robust brain screening 159-209 Availability of data
as recently proposed by the Society of Brain Mapping and
Therapeutics, as well as psychological and pharmacological Not applicable.
84
treatment approaches espoused herein. 210-257 References
Notably, each year, over a million adolescents globally
succumb to preventable or treatable causes. Psychosocial 1. Miller M, Chen ALC, Stokes SD, et al. Early intervention of
intravenous KB220IV--neuroadaptagen amino-acid therapy
factors are the strongest factors associated with drug abuse, (NAAT) improves behavioral outcomes in a residential
bullying, attempted suicide, and sleep deprivation resulting addiction treatment program: A pilot study. J Psychoactive
from bullying. 258-316 The Carter Center has estimated that the Drugs. 2012;44(5):398-409.
addiction crisis, if continues to worsen at the same rate, may cost doi: 10.1080/02791072.2012.737727
the US approximately 16 trillion dollars by 2030. Furthermore,
the neurodevelopment of children could be compromised by 2. Miller DK, Bowirrat A, Manka M, et al. Acute intravenous
™
maternal usage of opioids and other drugs during pregnancy. synaptamine complex variant KB220 “normalizes”
A high rate of DNA polymorphic antecedents compounds neurological dysregulation in patients during protracted
the epigenetic insults involving the methylation of specific abstinence from alcohol and opiates as observed using
quantitative electroencephalographic and genetic analysis
essential genes related to normal brain function. Myelination for reward polymorphisms: Part 1, pilot study with 2 case
in the frontal cortex, a process known to extend until the late reports. Postgrad Med. 2010;122(6):188-213.
20s, delays proficient executive function and decision-making
abilities. Understanding this delay in brain development, doi: 10.3810/pgm.2010.11.2236
along with the presence of potential high-risk antecedent 3. Blum K, Chen TJH, Downs BW, et al. Synaptamine (SG8839)
polymorphic variants or alleles and generational epigenetics, an amino-acid enkephalinase inhibition nutraceutical
provides a clear rationale to mimic fitness programs with an improves recovery of alcoholics, a subtype of reward deficiency
adaptable BHC. Implementing the BHC within the educational syndrome (RDS). Trends Appl Sci Res. 2007;2(2):132-138.
systems in the US and other countries might be a good starting 4. Blum K, Liu Y, Wang W, et al. rsfMRI effects of KB220Z on
™
point for proactive therapies aimed at reducing juvenile mental neural pathways in reward circuitry of abstinent genotyped
health problems and, eventually, criminal activities, addiction, heroin addicts. Postgrad Med. 2015;127(2):232-241.
and other behaviors associated with RDS. doi: 10.1080/00325481.2015.994879

Acknowledgments 5. Blum K, Chen AL, Chen TJ, et al. Activation instead of
blocking mesolimbic dopaminergic reward circuitry is a
None. preferred modality in the long term treatment of reward
deficiency syndrome (RDS): A commentary. Theor Biol Med
Funding Model. 2008;5:24.
None. doi: 10.1186/1742-4682-5-24
Conflict of interest 6. Gold MS, Baron D, Bowirrat A, Blum K. Neurological
correlates of brain reward circuitry linked to opioid use
Kenneth Blum is the holder of both USA and foreign disorder (OUD): Do homo sapiens acquire or have a reward
patents related to kb220 and gars. Other authors declare no deficiency syndrome? J Neurol Sci. 2020;418:117137.
conflicts of interest. doi: 10.1016/j.jns.2020.117137
Author contributions 7. Martins SS, Sampson L, Cerdá M, Galea S. Worldwide
prevalence and trends in unintentional drug overdose:
Conceptualization: Kenneth Blum, Eric Braverman A systematic review of the literature. Am J Public Health.
Visualization: Abdalla Bowirrat 2015;105(11):e29-e49.

Volume 7 Issue 2 (2024) 11 doi: 10.36922/itps.1472