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INNOSC Theranostics and
Pharmacological Sciences LMWH for VTE prophylaxis in acute stroke patients

the risk factors in both Groups A and B. Strangely, a small Consent for publication
number of the population assessed tend to have cancer of
various organs that may also contribute to VTE formation. Not applicable.
Table 2 shows the patient demographics of all 20 patients Availability of data
from Groups A and B with DVTs and PEs.
Data are available from the corresponding author upon
The current study had several limitations. One reasonable request.
apparent shortcoming of this analysis is that potential
risk factors, including obesity, dehydration, and family References
history of thromboembolism, were not covered in this 1. Bajenaru O, Antochi F, Balasa R, et al. Assessment of venous
study. Another pitfall is that Group B consisted of a small thromboembolism prophylaxis in neurological patients
number of subjects (only 752 patients), who were recruited with restricted mobility-VTE-NEURO Study. Maedica.
over a shorter period of time (12 months versus 19 months 2014;9(1):6-14.
in Group A), preventing us from exploring the long-term
significance of LMWH in reducing mortality and morbidity. 2. Kelly J, Rudd A, Lewis R, Hunt BJ. Venous thromboembolism
after acute stroke. Stroke. 2001;32(1):262-267.
Finally, although no definite cases of symptomatic HT
were detected in either Groups A or B, this observational doi: 10.1161/01.STR.32.1.262
study was not statistically powered enough to ascertain the 3. Dennis M, Mardi N, Graham C, et al. for the CLOTS, trials
significance of the findings. collaboration. The timing, extent, progression and regression
of DVT in immobile stroke patients: Observational data
6. Conclusion from the CLOTS randomized trials. J Thromb Haem.
There are numerous controversies over the utilization of 2011;9:2193-2200.
VTE prophylaxis in the management of acute ischemic doi: 10.1111/j.1538-7836.2011.04486.x
stroke. According to our analysis, early use of LMWHs was 4. Dennis M, Caso V, Kappelle LJ, Pavlovic A, Sandercock P,
better tolerated as a form of VTE prophylaxis. However, European Stroke Organisation. European Stroke
given the short-term nature of this project, we cannot Organisation (ESO) guidelines for prophylaxis for venous
establish the long-term significance of LMWH in reducing thromboembolism in immobile patients with acute
death and disability rates, and thus, additional large trials are ischaemic stroke. Eur Stroke J. 2016;1(1):6-19.
warranted to validate the efficacy of earlier use of LMWH. doi: 10.1177/2396987316628384
Acknowledgments 5. Kelly J, Rudd A, Lewis RR, et al. Venous thromboembolism
after acute ischemic stroke: A prospective study using
The authors would like to thank the resident doctors magnetic resonance direct thrombus imaging. Stroke.
working in the stroke department for their help with this 2004;35:2320-2325.
project.
doi: 10.1161/01.STR.0000140741.13279.4f
Funding 6. Warlow C, Ogston D, Douglas AS. Deep venous thrombosis
of the legs after strokes. Part I--incidence and predisposing
None. factors. Br Med J. 1976;1(6019):1178-1181.
Conflict of interest doi: 10.1136/bmj.1.6019.1178

The authors declare they have no competing interests. 7. Chen G, Wang A, Zhao X, et al. Frequency and risk factors
of spontaneous hemorrhagic transformation following
Author contributions ischemic stroke on the initial brain CT or MRI: Data from
the China National Stroke Registry (CNSR). Neurol Res.
Conceptualization: Revin Thomas 2016;38(6):538-544.
Formal analysis: All authors
Investigation: Faizan A. Sandhu doi: 10.1080/01616412.2016.1187864
Methodology: All authors 8. Paciaroni M, Agnelli G, Corea F, et al. Early hemorrhagic
Writing – original draft: Faizan A. Sandhu transformation of brain infarction: rate, predictive factors,
Writing – review & editing: All authors and influence on clinical outcome: Results of a prospective
multicenter study. Stroke. 2008;39(8):2249-2256.
Ethics approval and consent to participate doi: 10.1161/STROKEAHA.107.510321
Not applicable. 9. Toni D, Fiorelli M, Bastianello S, et al. Hemorrhagic

Volume 7 Issue 4 (2024) 6 doi: 10.36922/itps.3250