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INNOSC Theranostics and
            Pharmacological Sciences                                Cholesteatoma enrichment pathways for drug repurposing



            Author contributions                                  dysfunction as a major nutritional and lifestyle target for
                                                                  healthy aging. Maturitas. 2023;170:51-57.
            Conceptualization: Ioannis M. Vlastos, John Hajiioannou
            Formal analysis: Ioannis M. Vlastos, Kalliopi Gkouskou,     doi: 10.1016/j.maturitas.2023.01.013
            Investigation: Mohannad Almomani, Nikolaos Drimalas  8.   Yoshikawa M, Kojima H, Wada K,  et al. Identification of
            Writing – original draft: Ioannis M. Vlastos, Mohannad   specific gene expression profiles in fibroblasts derived from
               Almomani                                           middle ear cholesteatoma. Arch Otolaryngol Head Neck Surg.
            Writing – review & editing: Ioannis M. Vlastos, John   2006;132(7):734-742.
               Hajiioannou, Nikolaos Drimalas                     doi: 10.1001/archotol.132.7.734
            Ethics approval and consent to participate         9.   Cardenas  R,  Prinsley  P,  Philpott  C,  et al.  Whole  exome
                                                                  sequencing study identifies candidate loss of function
            Not applicable.                                       variants and locus heterogeneity in familial cholesteatoma.
                                                                  PLoS One. 2023;18(7):e0272174.
            Consent for publication                               doi: 10.1371/journal.pone.0272174

            Not applicable.                                    10.  Tokuriki M, Noda I, Saito T, et al. Gene expression analysis
                                                                  of human middle ear cholesteatoma using complementary
            Availability of data                                  DNA arrays. Laryngoscope. 2003;113(5):808-814.

            Data are available from the corresponding author upon      doi: 10.1097/00005537-200305000-00008
            reasonable request.                                11.  Macias  JD,  Gerkin  RD,  Locke  D, Macias MP. Differential

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            Volume 8 Issue 3 (2025)                        111                               doi: 10.36922/itps.2571
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