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Journal of Clinical and
            Basic Psychosomatics                                             Quality of life in patients with atopic dermatitis




            Table 4. Analysis of factors influencing depression
            Projects                        HADS‑D             Fisher’s exact test   Logistic regression analysis
                                   No or suspected   Abnormal   Chi‑square   P‑value  Wald  P‑value  OR (95% CI)
                                   depression (%)  depression (%)  value
            Gender
             Male                     22 (29.3)    8 (25.8)              0.815  0.151  0.697         -
             Female                   53 (70.7)    23 (74.2)
            Age
             25 and below             19 (25.3)    12 (38.7)    3.679    0.297  2.393  0.495         -
             26 – 35 years old        30 (40.0)    7 (22.6)
             36 – 45 years old        13 (17.3)    5 (16.1)
             46 years old and above   13 (17.3)    7 (22.6)
            Education level
             Middle school and below  11 (14.7)    10 (32.3)    5.406    0.067  4.679  0.031  10.374 (1.246 – 86.398)
             University               50 (66.7)    19 (61.3)                   0.801   0.371  2.207 (0.390 – 12.488)
             Graduate student and above  14 (18.7)  2 (6.5)
            Employment status
             Unemployed               30 (40.0)    15 (48.4)             0.518  0.072  0.789         -
             Employed                 45 (60.0)    16 (51.6)
            Working environment
             Indoor                   55 (73.3)    23 (74.2)    4.342    0.102  1.549  0.213  2.395 (0.605 – 9.471)
             Outdoor                  1 (1.3)       3 (9.7)                    4.583   0.032  21.945 (1.298 – 270.948)
             Both                     19 (25.3)    5 (16.1)
            Work nature
             Light                    11 (14.7)    6 (19.4)     1.06     0.807  2.36   0.501         -
             Intellectual             45 (60.0)    18 (58.1)
             Manual                   6 (8.0)       1 (3.2)
             Heavy                    13 (17.3)    6 (19.4)
            Atopic comorbidities
             None                     60 (80.0)    20 (64.5)    2.841    0.092  2.772  0.096         -
             Exist                    15 (20.0)    11 (35.5)
             DLQI                   6.0 (3.0 – 10.0)  10.0 (6.0 – 12.0)  −3.158  <0.01        -
             HADS-D                 5.0 (4.0 – 8.0)  12.0 (11.0 – 14.0)  −8.1  <0.01          -
            Note: The logistic regression equation did not include variables with P>0.05, so there was no odds ratio (OR) value for this variable, and DLQI and
            HADS-D were not subjected to multifactorial analysis.
            Abbreviations: DLQI: Dermatology life quality index; HADS-A: Hospital anxiety and depression scale anxiety; HADS-D: Hospital anxiety and
            depression scale depression.

            Table 5. Spearman’s rank‑order correlation analysis of the   studies, the Taiwan (region) and Singapore studies, and the US
            three                                              and German studies, but culture does have a profound effect
                                                               on physical and mental health with regard to the regulation
            Projects           Anxiety level  Depression level  of negative emotions . The low average HADS-A score
                                                                                [33]
                               r     P‑value   r    P‑value    in our study may be because of the mild symptoms among
            Degree of QOL impact  0.543  <0.01  0.377  <0.01   AD patients in the survey population, while the proportion
            Anxiety level                    0.660   <0.01     of moderate and severe AD patients in other areas in other
            Abbreviation: QOL: Quality of life.                studies is higher. The high average HADS-D score may be
                                                               because the proportion of people in middle school and below
            and reaction of negative emotions. However, the findings   or those working in an outdoor environment as a whole is
            from the study do not explain the discrepancies between our   higher than that of other regional studies. It is well known that

            Volume 1 Issue 1 (2023)                         7                        https://doi.org/10.36922/jcbp.0956
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