Page 21 - JCTR-11-1

Journal of Clinical and

Translational Research

ORIGINAL ARTICLE
Name ORCID Association between pesticide exposure and
Nicholas Kounis https://orcid.org/0000-0002-9751-6710
Soheila Pourmasumi https://orcid.org/0000-0003-1028-2825 ischemic heart disease among adults who took
Parvin Khalili https://orcid.org/0000-0002-8124-2129 part in the Rafsanjan cohort study

Zahra Jamali https://orcid.org/0000-0002-7705-431X
Hamid Hakimi https://orcid.org/0000-0002-2686-4750 Soheila Pourmasumi 1,2 , Parvin Khalili 1,3 , Zahra Jamali 4 ,
Ali Esmaeili Nadimi 4 , Hamid Hakimi 5 , Soudeh Khanamani Falahati-pour 6 ,
Soudeh Khanamani Falahati-pour https://orcid.org/0000-0002-3539-8982
Alireza Vakilian 4,7 , Monavar Naderi 8 , Zahra Ahmadi 6 ,
Alireza Vakilian https://orcid.org/0000-0001-5413-5400 Mohammad Reza Vazifeshenas 9 , Alireza Nazari 1,10 , Fatemeh Ayoobi 11 ,
13
Monavar Naderi https://orcid.org/0000-0002-4710-6588 Ioanna Koniari 12 , Nicholas G. Kounis *
1 Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences,
Zahra Ahmadi https://orcid.org/0000-0002-7605-9303 Rafsanjan, Iran
*Corresponding author:
Mohammad Reza Vazifeshenas https://orcid.org/0000-0002-7248-3641 Nicholas Kounis 2 Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical
E-mail: ngkounis@otenet.gr Sciences, Rafsanjan, Iran
Alireza Nazari https://orcid.org/0000-0001-8352-793X
Citation: Pourmasumi S, Khalili P, 3 Department of Epidemiology, School of Public Health, Rafsanjan University of Medical Sciences,
Fatemeh Ayoobi https://orcid.org/0000-0003-2901-7327 Jamali Z, et al. Association between Rafsanjan, Iran
pesticide exposure and ischemic
Ioanna Koniari https://orcid.org/0000-0002-1033-5299 heart disease among adults
who took part in the Rafsanjan
Ali Esmaeili Nadimi https://orcid.org/0000-0001-8031-0073 cohort study. J Clin Transl Res.
2025;11(1):15-26. Abstract
doi: 10.36922/jctr.22.00187
Background: Cardiovascular disease (CVD) is recognized as a major cause of
Received: November 5, 2022
death worldwide. Sustained exposure to pesticides is a significant factor that can
1st revised: November 21, 2022 increase morbidity and mortality rates due to CVD. Aims: This study aimed to
2nd revised: December 11, 2022 investigate the effects of pesticide exposure on CVD among adult participants
in the Rafsanjan cohort study (RCS). Methods: Data were analyzed from 9,990
3rd revised: March 29, 2023
adult participants of RCS as a part of the Prospective Epidemiological Research
4th revised: April 9, 2023 Studies in IRAN. Data on personal habits, lifestyle, demographic characteristics,
5th revised: June 10, 2023 comorbidity history, physical activity, and pesticide exposure were collected via
face-to-face questionnaires. The prevalence of ischemic heart disease (IHD) was
6th revised: November 19, 2024
assessed based on the medical history questionnaire of the participants. IHD was
7th revised: January 7, 2025 defined as a cardiac condition (either IHD or heart failure) diagnosed by a physician.
Accepted: January 7, 2025 Results: The mean age of participants with IHD was significantly higher than that
of healthy participants (P < 0.001). Furthermore, the prevalence of IHD was higher
Published online: February 3,
2025 in men compared to women (P = 0.003). In addition, the duration of pesticide
exposure at home in men was significantly associated with IHD (P = 0.047). None
Copyright: © 2025 Author(s).
This is an open-access article of the other variables demonstrated a significant correlation with the prevalence
distributed under the terms of the of IHD. Conclusion: Pesticide exposure may increase the risk of IHD, as indicated
Creative Commons AttributionNon- by the results of the studied population. Implementing continuous, well-structured
Commercial 4.0 International (CC
BY-NC 4.0), which permits all educational programs for individuals professionally exposed to pesticides is
non-commercial use, distribution, important. These programs should focus on personal protection and the safe use
and reproduction in any medium, of pesticides to prevent or decrease the risk of CVDs. Relevance for patients: It is
provided the original work is
properly cited. important for farmers, agricultural workers, and those living near agricultural areas
to understand the risks that pesticides pose to cardiovascular health.
Publisher’s Note: AccScience
Publishing remains neutral with
regard to jurisdictional claims in
published maps and institutional Keywords: Cardiovascular disease; Cohort study; Ischemic heart disease; Pesticides;
affiliations Prospective epidemiological research studies in IRAN

Volume 11 Issue 1 (2025) 15 doi: 10.36922/jctr.22.00187