Page 57 - JCTR-11-1
P. 57
Journal of Clinical and
Translational Research Hesperidin enhances repair of γ-irradiated wounds
2020;28(4):979-992. and sub-chronic oral toxicity studies of hesperidin isolated
from orange peel extract in Sprague Dawley rats. Regul
doi: 10.1007/s10787-020-00686-7
Toxicol Pharmacol. 2019;105:77-85.
43. Valls RM, Pedret A, Calderón-Pérez L, et al. Effects of
hesperidin in orange juice on blood and pulse pressures in doi: 10.1016/j.yrtph.2019.04.001
mildly hypertensive individuals: A randomized controlled 53. Mayumi K, Seiko T, Masa-Aki S, Masao H, Shoji F,
trial (Citrus study). Eur J Nutr. 2021;60(3):1277-1288. Nobuyuki I. Subchronic toxicity study of methyl hesperidin
in mice. Toxicol Lett. 1993;69(1):37-44.
doi: 10.1007/s00394-020-02279-0
doi: 10.1016/0378-4274(93)90143-L
44. Tanaka T, Makita H, Kawabata K, et al. Chemoprevention
of azoxymethane-induced rat colon carcinogenesis by the 54. Abdel-Raheem IT, Abdel-Ghany AA. Hesperidin alleviates
naturally occurring flavonoids, diosmin and hesperidin. doxorubicin-induced cardiotoxicity in rats. J Egypt Natl
Carcinogenesis. 1997;18(5):957-965. Canc Inst. 2009;21(2):175-184.
doi: 10.1093/carcin/18.5.957 55. Merzoug S, Toumi ML. Effects of hesperidin on
formaldehyde-induced toxicity in pregnant rats. EXCLI J.
45. Vabeiryureilai M, Lalrinzuali K, Jagetia GC.
Chemopreventive effect of hesperidin, a citrus bioflavonoid 2017;16:400-413.
in two stage skin carcinogenesis in Swiss albino mice. doi: 10.17179/EXCLI2017-142
Heliyon. 2019;5(10):e02521.
56. Caglayan C, Kandemir FM, Darendelioğlu E, Küçükler S,
doi: 10.1016/j.heliyon.2019.e02521 Ayna A. Hesperidin protects liver and kidney against sodium
fluoride-induced toxicity through anti-apoptotic and anti-
46. Hermawan A, Khumaira A, Ikawati M, et al. Identification
of key genes of hesperidin in inhibition of breast cancer stem autophagic mechanisms. Life Sci. 2021;281:119730.
cells by functional network analysis. Comput Biol Chem. doi: 10.1016/J.LFS.2021.119730
2021;90:107427.
57. Li W, Kandhare AD, Mukherjee AA, Bodhankar SL.
doi: 10.1016/j.compbiolchem.2020.107427 Hesperidin, a plant flavonoid accelerated the cutaneous
wound healing in streptozotocin-induced diabetic rats:
47. Kurowska EM, Spence JD, Jordan J, et al. HDL-
cholesterol-raising effect of orange juice in subjects with Role of TGF-ß/Smads and Ang-1/Tie-2 signaling pathways.
hypercholesterolemia. Am J Clin Nutr. 2000;72(5):1095-1100. EXCLI J. 2018;17:399-419.
doi: 10.17179/excli2018-1036
doi: 10.1093/ajcn/72.5.1095
58. Pradeep K, Park SH, Ko KC. Hesperidin a flavanoglycone
48. Chiba H, Uehara M, Wu J, et al. Hesperidin, a citrus flavonoid,
inhibits bone loss and decreases serum and hepatic lipids in protects against γ-irradiation induced hepatocellular
damage and oxidative stress in Sprague-Dawley rats. Eur J
ovariectomized mice. J Nutr. 2003;133(6):1892-1897.
Pharmacol. 2008;587(1-3):273-280.
doi: 10.1093/jn/133.6.1892
doi: 10.1016/j.ejphar.2008.03.052
49. Hou M, Man M, Man W, et al. Topical hesperidin improves
epidermal permeability barrier function and epidermal 59. Wang Y, Yu H, Zhang J, Gao J, Ge X, Lou G. Hesperidin
differentiation in normal murine skin. Exp Dermatol. inhibits HeLa cell proliferation through apoptosis mediated
2012;21(5):337-340. by endoplasmic reticulum stress pathways and cell cycle
arrest. BMC Cancer. 2015;15(1):682.
doi: 10.1111/j.1600-0625.2012.01455.x
doi: 10.1186/s12885-015-1706-y
50. Dobiaš L, Petrová M, Vojtko R, Kristová V. Long-term
treatment with hesperidin improves endothelium- 60. Zhao W, Chen Y, Zhang X. Hesperidin-triggered necrosis-
dependent vasodilation in femoral artery of spontaneously like cell death in skin cancer cell line A431 might be prompted
hypertensive rats: The involvement of NO-synthase and Kv by ros mediated alterations in mitochondrial membrane
channels. Phyther Res. 2016;30(10):1665-1671. potential. Int J Clin Exp Med. 2018;11(3):1948-1954.
61. Xiong H, Wang J, Ran Q, et al. Hesperidin: A therapeutic
doi: 10.1002/ptr.5670
agent for obesity. Drug Des Devel Ther. 2019;13:3855-3866.
51. Akamo AJ, Ojelabi AO, Somade OT, et al. Hesperetin-7-
O-rhamnoglucoside ameliorates dichlorvos-facilitated doi: 10.2147/DDDT.S227499
cardiotoxicity in rats by counteracting ionoregulatory, ion 62. Musa AE, Omyan G, Esmaely F, Shabeeb D. Radioprotective
pumps, redox, and lipid homeostasis disruptions. Toxicol effect of hesperidin: A systematic review. Medicina (Kaunas).
Reports. 2024;13:101698. 2019;55(7):370.
doi: 10.1016/J.TOXREP.2024.101698 doi: 10.3390/medicina55070370
52. Li Y, Kandhare AD, Mukherjee AA, Bodhankar SL. Acute 63. Woessner JF Jr. The determination of hydroxyproline in
Volume 11 Issue 1 (2025) 51 doi: 10.36922/jctr.24.00049

