Page 50 - JCTR-11-5
P. 50
Journal of Clinical and
Translational Research Vaginal microbiota in menopause pathologies
12. Conclusion References
The intestinal, urinary, and vaginal microbiomes form 1. Muhleisen AL, Herbst-Kralovetz MM. Menopause and the
an interconnected ecosystem whose alteration during vaginal microbiome. Maturitas. 2016;91:42-50.
menopause, primarily caused by estrogen deficiency, doi: 10.1016/j.maturitas.2016.05.015
is associated with various gynecological and urological 2. Zhao F, Hu X, Ying C. Advances in research on the
disorders. Vaginal dysbiosis clinically manifested as relationship between vaginal microbiota and adverse
dryness, atrophy, and urinary symptoms, significantly pregnancy outcomes and gynecological diseases.
affects women’s quality of life. Its management with local Microorganisms. 2023;11(4):991.
estrogens and probiotics has shown consistent benefits.
Microbiota imbalance also influences urological health, doi: 10.3390/microorganisms11040991
and its modulation could serve as a promising tool against 3. Ovalle A, Oyarzún E. Microbiota y perfil inmunológico
UTIs and pelvic floor dysfunctions, although further vaginal de la embarazada propensa a parto prematuro por
evidence is needed to confirm its effectiveness. Moreover, infección bacteriana ascendente. Rev Chil Obstet Ginecol.
the VM appears to play a role in the progression of 2024;89(3):164-181.
gynecological cancers such as cervical, endometrial, and doi: 10.24875/rechog.23000039
potentially ovarian cancer, through mechanisms involving 4. De Oliveira NS, De Lima ABF, De Brito JCR, Sarmento ACA,
persistent HPV infection and the presence of bacteria Gonçalves AKS, Eleutério J Jr. Postmenopausal vaginal
associated with BV, opening the possibility for preventive microbiome and microbiota. Front Reprod Health.
strategies based on microbiome modulation. 2022;3:780931.
This study’s strengths include its narrative review doi: 10.3389/frph.2021.780931
design, which incorporates a rigorous selection of relevant,
low-bias studies supported by current evidence from 5. Shen L, Zhang W, Yuan Y, Zhu W, Shang A. Vaginal
recognized databases, thereby reinforcing the clinical microecological characteristics of women in different
physiological and pathological period. Front Cell Infect
conclusions on postmenopausal microbiota. However, Microbiol. 2022;12:959793.
the narrative approach does not apply systematic quality
criteria or a reproducible search strategy. In addition, doi: 10.3389/fcimb.2022.959793
the heterogeneity of the included studies and the lack of 6. Vaughan MH, Mao J, Karstens LA, et al. The urinary
randomized controlled trials limit the ability to establish microbiome in postmenopausal women with recurrent
definitive causal relationships in all cases. urinary tract infections. J Urol. 2021;206(5):1222-1231.
Acknowledgments doi: 10.1097/JU.0000000000001940
7. Naji A, Siskin D, Woodworth MH, Lee JR, Kraft CS,
None. Mehta N. The role of the gut, urine, and vaginal microbiomes
Funding in the pathogenesis of urinary tract infection in women and
consideration of microbiome therapeutics. Open Forum
None. Infect Dis. 2024;11(9):ofae471.
doi: 10.1093/ofid/ofae471
Conflict of interest
8. Barrea L, Verde L, Auriemma RS, et al. Probiotics and
The author declares no conflict of interest. prebiotics: Any role in menopause-related diseases? Curr
Nutr Rep. 2023;12(1):83-97.
Author contributions
doi: 10.1007/s13668-023-00462-3
This is a single-authored article.
9. Kalia N, Singh J, Kaur M. Microbiota in vaginal health and
Ethics approval and consent to participate pathogenesis of recurrent vulvovaginal infections: A critical
review. Ann Clin Microbiol Antimicrob. 2020;19(1):5.
Not applicable.
doi: 10.1186/s12941-020-0347-4
Consent for publication 10. Deka N, Hassan S, Seghal Kiran G, Selvin J. Insights into
Not applicable. the role of vaginal microbiome in women’s health. J Basic
Microbiol. 2021;61(12):1071-1084.
Availability of data doi: 10.1002/jobm.202100421
Not applicable. 11. Ovalle A, Martínez MA. In: Guzmán E, editor. CAPÍTULO
Volume 11 Issue 5 (2025) 44 doi: 10.36922/JCTR025150016

