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Olatunji et al. | Journal of Clinical and Translational Research 2023; 9(5): 357-368 359
development projects have become a key component in improving research [24]. This disparity needs to be improved for African
research capacity in Africa [21]. These projects focus on researchers, limiting their ability to compete globally and
establishing or upgrading laboratory facilities, research centers, collaborate effectively with international counterparts.
and clinical trial sites, ensuring researchers have access to modern Nevertheless, some shining examples of African-led research
equipment, well-maintained facilities, and reliable resources. This centers have made substantial contributions to the scientific
infrastructure support enables researchers to carry out their work community. One such example is the South African Tuberculosis
efficiently and effectively. Vaccine Initiative (SATVI), a world-renowned research center
Collaborations with international partners benefit research dedicated to developing new vaccines for tuberculosis [25].
capacity building in Africa [22]. These partnerships often provide SATVI’s pioneering work showcases the potential for African-
funding, technical assistance, and mentorship, further strengthening led research to drive innovation and address critical healthcare
the research capabilities of African institutions [22]. The transfer challenges that disproportionately affect the continent. Similarly,
of knowledge, expertise, and technology from international the African Institute for Mathematical Sciences (AIMS) stands as a
partners to African researchers contributes to the overall growth pan-African network of centers of excellence that provide advanced
and advancement of research in the region. The ultimate goal education in mathematical sciences to students from across the
of these collective efforts is to empower African researchers continent [26]. By nurturing talent and fostering interdisciplinary
and institutions to conduct impactful research that addresses the collaborations, AIMS exemplifies the transformative impact
specific health challenges African populations face. By investing of African-led initiatives in promoting research and knowledge
in research infrastructure and capacity building, African countries dissemination within and beyond the region. Despite these
can generate locally relevant evidence, inform health policies, and notable success stories, the need for cutting-edge research
improve health-care delivery. Consequently, these efforts lead to facilities and advanced technology is a significant barrier to
better health outcomes for African communities. fully unlocking Africa’s research potential. Addressing this
scarcity requires targeted efforts from both local and international
3. Challenges in Clinical and Translational Research in stakeholders, including governments, funding agencies, and
Africa private institutions. By investing in developing and modernizing
research infrastructure, Africa can enable researchers to thrive and
Clinical and translational research in Africa faces several contribute meaningfully to global scientific advancements.
significant challenges that must be addressed to foster progress More financial support and the need for grants present
and development in the field Table 1. One primary challenge is formidable barriers to clinical and translational research
the limited availability of research infrastructure and resources. endeavors in Africa. These projects require substantial funding
Despite remarkable contributions from some African-led research to cover essential aspects such as personnel remuneration,
centers, many African universities and institutions still need purchasing laboratory supplies, efficient data management, and
more cutting-edge laboratories, advanced technology, and well- participant recruitment. Unfortunately, funding availability is
equipped facilities for conducting rigorous clinical trials and often limited, leading to project delays, compromised research
translational research [23]. This dearth significantly hampers outcomes, and difficulties in attracting and retaining highly
the scope and quality of research conducted on the continent, skilled researchers [27]. Remarkably, Africa receives a mere
impeding scientific advancements and hindering the realization of 1% of the global investment in research and development
Africa’s full research potential. In contrast, research institutions (R&D), with Egypt, Nigeria, and South Africa contributing up
in developed nations often boast state-of-the-art laboratories with to 67% of the total domestic spending on R&D in the region
cutting-edge technology and facilities that enable groundbreaking while holding a meager 0.1% of the world’s patents [28]. Such

Table 1. Challenges, opportunities, and policy recommendations in advancing clinical and translational research in Africa
Challenges Opportunities Policy recommendations
Limited research infrastructure Diverse populations and unique genetic backgrounds Increase research funding and budget allocation
Scarcity of resources Abundant biodiversity Establish research partnerships and networks
High burden of diseases Traditional medicine practices Promote ethical research practices and oversight
Ethical considerations and regulatory hurdles Collaboration and knowledge sharing among institutions Enhance data management and sharing mechanisms
Data collection and management challenges Public-private partnerships Foster collaboration between African
institutions and international partners
Lack of trained healthcare Integration of digital health technologies Invest in health-care workforce
professionals and researchers training and capacity building
Access to advanced technologies and equipment Leveraging international collaborations Provide access to advanced technologies and equipment
Language and cultural barriers Strengthening research capacity and training Address language and cultural barriers
Funding constraints Investing in research infrastructure Develop sustainable funding mechanisms and grants
Political and socioeconomic factors Patient-centric approach to research Create a supportive policy environment for research

DOI: http://dx.doi.org/10.18053/jctres.09.202305.23-00079