Page 118 - OR-1-1

25. Goldring MB, Otero M. Inflammation in osteoarthritis. Curr doi: 10.1016/j.ijbiomac.2025.140823
Opin Rheumatol. 2011;23(5):471-478.
35. Paggi C, Venzac B, Leijten J, et al. Cartilage-on-chip: A multi-
doi: 10.1097/BOR.0b013e328349c2b1 modal platform to study human chondrocyte’s response to
mechanical stimuli. Osteoarthritis Cartil. 2020;28:S176-S177.
26. Sellam J, Berenbaum F. The role of synovitis in
pathophysiology and clinical symptoms of osteoarthritis. doi: 10.1016/j.joca.2020.02.287
Nat Rev Rheumatol. 2010;6(11):625-635.
36. Banh L, Cheung K, Perera K, et al. Development of a novel
doi: 10.1038/nrrheum.2010.159 synovial joint-on-a-chip to model the complex osteoarthritic
knee microenvironment. Osteoarthritis Cartil. 2023;31:S57.
27. Kapoor M, Martel-Pelletier J, Lajeunesse D, et al. Role
of proinflammatory cytokines in the pathophysiology of doi: 10.1016/j.joca.2023.01.552
osteoarthritis. Nat Rev Rheumatol. 2011;7(1):33-42.
37. Reihs EI, Hayer S, Toegel S, et al. 405 - Advancing synovial
doi: 10.1038/nrrheum.2010.196 tissue models with animal-free organs-on-a-chip – a
matter of synovial structure and function in the context
28. Martel-Pelletier J, Barr AJ, Cicuttini FM, et al. Osteoarthritis.
Nat Rev Dis Primers. 2016;2:16072. of osteoarthritic remodelling. Osteoarthritis Cartil.
2024;32:S287-S288.
doi: 10.1038/nrdp.2016.72
doi: 10.1016/j.joca.2024.02.418
29. Jhun J, Cho KH, Lee DH, et al. Oral administration of
Lactobacillus rhamnosus ameliorates the progression of 38. Kahraman E, Vasconcelos D, Ribeiro B, et al.
osteoarthritis by inhibiting joint pain and inflammation. Deciphering cartilage neuro-immune interactions and
Cells. 2021;10(5):1057. innervation profile through 3D engineered osteoarthritic
micropathophysiological system. Mater Today Bio.
doi: 10.3390/cells10051057 2025;31:101491.
30. Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. doi: 10.1016/j.mtbio.2025.101491
2019;393(10182):1745-1759.
39. Nahak BK, Mishra A, Preetam S, et al. Advances in organ-
doi: 10.1016/s0140-6736(19)30417-9 on-a-chip materials and devices. ACS Appl Bio Mater.
31. Paggi CA, Hendriks J, Karperien M, et al. Emulating the 2022;5(8):3576-3607.
chondrocyte microenvironment using multi-directional doi: 10.1021/acsabm.2c00041
mechanical stimulation in a cartilage-on-chip. Lab
Chip. 2022;22(9):1815-1828. 40. Ying-Jin S, Yuste I, González-Burgos E, et al. Fabrication
of organ-on-a-chip using microfluidics. Bioprinting.
doi: 10.1039/d1lc01069g 2025;46:e00394.
32. Lin Z, Li Z, Li EN, et al. Osteochondral tissue chip derived doi: 10.1016/j.bprint.2025.e00394
from iPSCs: Modeling OA pathologies and testing drugs.
Front Bioeng Biotechnol. 2019;7:411. 41. Sun L, Bian F, Xu D, et al. Tailoring biomaterials for biomimetic
organs-on-chips. Mater Horiz. 2023;10(11):4724-4745.
doi: 10.3389/fbioe.2019.00411
doi: 10.1039/d3mh00755c
33. Liu H, Wu X, Liu R, et al. Cartilage-on-a-chip with magneto-
mechanical transformation for osteoarthritis recruitment. 42. Feng J, Neuzil J, Manz A, et al. Microfluidic trends in drug
Bioact Mater. 2024;33:61-68. screening and drug delivery. TrAC Trends Anal Chem.
2023;158:116821.
doi: 10.1016/j.bioactmat.2023.10.030
doi: 10.1016/j.trac.2022.116821
34. Sun Q, Zhang Y, Hu B, et al. Development of a dual-
responsive injectable GelMA/F127DA hydrogel for 43. Mousavi Shaegh SA, De Ferrari F, Zhang YS, et al.
enhanced cartilage regeneration in osteoarthritis: A microfluidic optical platform for real-time monitoring of
Harnessing MMP-triggered and mechanical stress- pH and oxygen in microfluidic bioreactors and organ-on-
induced release of therapeutic agents. Int J Biol Macromol. chip devices. Biomicrofluidics. 2016;10(4):044111.
2025;2025:140823. doi: 10.1063/1.4955155

Volume 1 Issue 1 (2025) 19 doi: 10.36922/or.8461