Page 22 - TD-1-1

Tumor Discovery Monocytes from single-cell analysis

9. Zhuang J, Wu Y, Chen L, et al., 2018, Single-cell mobility https://doi.org/10.1126/science.1142883
analysis of metastatic breast cancer cells. Advanced Science 22. Movahedi K, Laoui D, Gysemans C, et al., 2010, Different
(Weinheim, Baden-Wurttemberg, Germany), 5: 1801158.
tumor microenvironments contain functionally distinct
https://doi.org/10.1002/advs.201801158 subsets of macrophages derived from Ly6C(high)
monocytes. Cancer Res, 70(14): 5728–5739.
10. Trapnell C, 2015, Defining cell types and states with single-
cell genomics. Genome Res, 25: 1491–1498. https://doi.org/10.1158/0008-5472.CAN-09-4672
11. Grün D, van Oudenaarden A, 2015, Design and analysis of 23. Mildner A, Schönheit J, Giladi A, et al., 2017, Genomic
single-cell sequencing experiments. Cell, 163: 799–810. characterization of murine monocytes reveals C/EBPβ
transcription factor dependence of Ly6C cells. Immunity,
https://doi.org/10.1016/j.cell.2015.10.039
46(5): 849–862.e7.
12. Topalian SL, Hodi FS, Brahmer JR, et al., 2012, Safety, https://doi.org/10.1016/j.immuni.2017.04.018
activity, and immune correlates of anti-PD-1 antibody in
cancer. N Engl J Med, 366: 2443–2454. 24. van Galen P, Hovestadt V, Wadsworth Ii MH, et al., 2019, Single-
cell RNA-Seq reveals AML hierarchies relevant to disease
https://doi.org/10.1056/NEJMoa1200690
progression and immunity. Cell, 176(6): 1265–1281.e1224.
13. Powles T, Eder JP, Fine GD, et al., 2014, MPDL3280A (anti-
PD-L1) treatment leads to clinical activity in metastatic https://doi.org/10.1016/j.cell.2019.01.031
bladder cancer. Nature, 515: 558–562. 25. Zilionis R, Engblom C, Pfirschke C, et al., 2019, Single-cell
transcriptomics of human and mouse lung cancers reveals
https://doi.org/10.1038/nature13904
conserved myeloid populations across individuals and
14. Rizvi NA, Hellmann MD, Snyder A, et al., 2015, Cancer species. Immunity, 50(5): 1317–1334.e1310.
immunology. Mutational landscape determines sensitivity https://doi.org/10.1016/j.immuni.2019.03.009
to PD-1 blockade in non-small cell lung cancer. Science
(New York), 348: 124–128. 26. Puram SV, Tirosh I, Parikh AS, et al., 2017, Single-cell
transcriptomic analysis of primary and metastatic tumor
https://doi.org/10.1126/science.aaa1348
ecosystems in head and neck cancer. Cell, 171(7): 1611–1624.e24.
15. Ansell SM, Lesokhin AM, Borrello I, et al., 2015, PD-1 https://doi.org/10.1016/j.cell.2017.10.044
blockade with nivolumab in relapsed or refractory Hodgkin’s
lymphoma. N Engl J Med, 372(4): 311–319. 27. Passlick B, Flieger D, Ziegler-Heitbrock HW, 1989,
Identification and characterization of a novel monocyte
16. Robert C, Schachter J, Long GV, et al., 2015, Pembrolizumab subpopulation in human peripheral blood. Blood, 74(7):
versus ipilimumab in advanced melanoma. N Engl J Med, 2527–2534.
372(26): 2521–2532.
28. Olingy CE, Dinh HQ, Hedrick CC, 2019, Monocyte
https://doi.org/10.1056/NEJMoa1503093
heterogeneity and functions in cancer. J Leukocyte Biol,
17. Ostrand-Rosenberg S, Sinha P, 2009, Myeloid-derived 106(2): 309–322.
suppressor cells: Linking inflammation and cancer. https://doi.org/10.1002/JLB.4RI0818-311R
J Immunol (Baltimore, Md. 1950), 182(8): 4499–4506.
29. Villani AC, Satija R, Reynolds G, et al., 2017, Single-cell
https://doi.org/10.4049/jimmunol.0802740
RNA-seq reveals new types of human blood dendritic cells,
18. Auffray C, Sieweke MH, Geissmann F, 2009, Blood monocytes, and progenitors. Science (New York), 356(6335):
monocytes: Development, heterogeneity, and relationship eaah4573.
with dendritic cells. Annu Rev Immunol, 27: 669–692.
https://doi.org/10.1126/science.aah4573
https://doi.org/10.1146/annurev.immunol.021908.132557
30. Qian BZ, Li J, Zhang H, et al., 2011, CCL2 recruits
19. Shi C, Pamer EG, 2011, Monocyte recruitment during infection inflammatory monocytes to facilitate breast-tumour
and inflammation. Nat Rev Immunol, 11(11): 762–774. metastasis. Nature, 475(7355): 222–225.
https://doi.org/10.1038/nri3070 https://doi.org/10.1038/nature10138
20. Ziegler-Heitbrock L, Ancuta P, Crowe S, et al., 2010, 31. Schmall A, Al-Tamari HM, Herold S, et al., 2015,
Nomenclature of monocytes and dendritic cells in blood. Macrophage and cancer cell cross-talk via CCR2 and
Blood, 116(16): e74–e80. CX3CR1 is a fundamental mechanism driving lung cancer.
https://doi.org/10.1182/blood-2010-02-258558 Am J Respir Crit Care Med., 191(4): 437–447.
https://doi.org/10.1164/rccm.201406-1137OC
21. Auffray C, Fogg D, Garfa M, et al., 2007, Monitoring of
blood vessels and tissues by a population of monocytes with 32. Li X, Yao W, Yuan Y, et al., 2017, Targeting of tumour-
patrolling behavior. Science (New York), 317(5838): 666–670. infiltrating macrophages via CCL2/CCR2 signalling as a

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