Page 26 - TD-1-1
P. 26
Tumor Discovery Monocytes from single-cell analysis
tumour immunity and immunotherapy. Nat Rev Immunol, 106. Singhal S, Stadanlick J, Annunziata MJ, et al., 2019, Human
19(6): 369–382. tumor-associated monocytes/macrophages and their
regulation of T cell responses in early-stage lung cancer. Sci
https://doi.org/10.1038/s41577-019-0127-6
Transl Med, 11(479): eaat1500.
96. Zhu Y, Herndon JM, Sojka DK, et al., 2017, Tissue-resident
macrophages in pancreatic ductal adenocarcinoma originate https://doi.org/10.1126/scitranslmed.aat1500
from embryonic hematopoiesis and promote tumor 107. Laviron M, Boissonnas A, 2019, Ontogeny of tumor-
progression. Immunity, 47(2): 323–338.e6. associated macrophages. Front Immunol, 10: 1799.
https://doi.org/10.1016/j.immuni.2017.07.014 108. Müller S, Kohanbash G, Liu SJ, et al., 2017, Single-cell
profiling of human gliomas reveals macrophage ontogeny as
97. Sica A, Bronte V, 2007, Altered macrophage differentiation a basis for regional differences in macrophage activation in
and immune dysfunction in tumor development. J Clin the tumor microenvironment. Genome Biol, 18: 234.
Investig, 117(5): 1155–1166.
109. Bowman RL, Klemm F, Akkari L, et al., 2016, Macrophage
https://doi.org/10.1172/JCI31422
ontogeny underlies differences in tumor-specific education
98. Yin M, Li X, Tan S, et al., 2016, Tumor-associated in brain malignancies. Cell Rep, 17(9): 2445–2459.
macrophages drive spheroid formation during early https://doi.org/10.1016/j.celrep.2016.10.052
transcoelomic metastasis of ovarian cancer. J Clin Investig,
126(11): 4157–4173. 110. Balkwill F, Mantovani A, 2001, Inflammation and cancer:
Back to virchow? Lancet, 357(9255): 539–545.
https://doi.org/10.1172/JCI87252
https://doi.org/10.1016/S0140-6736(00)04046-0
99. Richards DM, Hettinger J, Feuerer M, 2013, Monocytes and
macrophages in cancer: development and functions. Cancer 111. Kumar V, Patel S, Tcyganov E, et al., 2016, The nature
Microenviron, 6(2): 179–191. of Myeloid-Derived suppressor cells in the tumor
microenvironment. Trends Immunol, 37(3): 208–220.
https://doi.org/10.1007/s12307-012-0123-x
https://doi.org/10.1016/j.it.2016.01.004
100. Martinez FO, Helming L, Gordon S, 2009, Alternative
activation of macrophages: An immunologic functional 112. Kumar V, Cheng P, Condamine T, et al., 2016, CD45
perspective. Annu Rev Immunol, 27: 451–483. phosphatase inhibits STAT3 transcription factor activity in
myeloid cells and promotes tumor-associated macrophage
https://doi.org/10.1146/annurev.immunol.021908.132532 differentiation. Immunity, 44(2): 303–315.
101. Mantovani A, Sozzani S, Locati M, et al., 2002, Macrophage https://doi.org/10.1016/j.immuni.2016.01.014
polarization: Tumor-associated macrophages as a paradigm
for polarized M2 mononuclear phagocytes. Trends Immunol, 113. Laoui D, Keirsse J, Morias Y, et al., 2016, The tumour
23(11): 549–555. microenvironment harbours ontogenically distinct dendritic
cell populations with opposing effects on tumour immunity.
https://doi.org/10.1016/s1471-4906(02)02302-5 Nat Commun, 7: 13720.
102. Minopoli M, Sarno S, Di Carluccio G, et al., 2020, Inhibiting https://doi.org/10.1038/ncomms13720
monocyte recruitment to prevent the pro-tumoral activity
of tumor-associated macrophages in chondrosarcoma. Cells, 114. Veglia F, Gabrilovich DI, 2017, Dendritic cells in cancer: The
9(4): 1062. role revisited. Curr Opin Immunol, 45: 43–51.
https://doi.org/10.1016/j.coi.2017.01.002
https://doi.org/10.3390/cells9041062
115. Broz ML, Binnewies M, Boldajipour B, et al., 2014, Dissecting
103. Murray PJ, Allen JE, Biswas SK, et al., 2014, Macrophage
activation and polarization: nomenclature and experimental the tumor myeloid compartment reveals rare activating
guidelines. Immunity, 41(1): 14–20. antigen-presenting cells critical for T cell immunity. Cancer
Cell, 26(5): 638–652.
https://doi.org/10.1016/j.immuni.2014.06.008
https://doi.org/10.1016/j.ccell.2014.09.007
104. Azizi E, Carr AJ, Plitas G, et al., 2018, Single-cell map
of diverse immune phenotypes in the breast tumor 116. He YF, Wang CQ, Yu Y, et al., 2015, Tie2-expressing
monocytes are associated with identification and prognoses
microenvironment. Cell, 174()5: 1293–1308.e36.
of hepatitis B virus related hepatocellular carcinoma after
https://doi.org/10.1016/j.cell.2018.05.060 resection. PLoS One, 10(11): e0143657.
105. Vitale I, Shema E, Loi S, et al., 2021, Intratumoral https://doi.org/10.1371/journal.pone.0143657
heterogeneity in cancer progression and response to 117. Awad RM, De Vlaeminck Y, Maebe J, et al., 2018, Turn
immunotherapy. Nat Med, 27(2): 212–224.
back the TIMe: Targeting tumor infiltrating myeloid cells to
https://doi.org/10.1038/s41591-021-01233-9 revert cancer progression. Front Immunol, 9: 1977.
Volume 1 Issue 1 (2022) 17 https://doi.org/10.36922/td.v1i1.4

