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Tumor Discovery

REVIEW ARTICLE
Advances in the study of the pathogenesis of

cancer-related cognitive impairment

1,2
Jiwei Jiang 1,2† , Zhongli Du , Yanli Wang , Hanping Shi , Wenyi Li ,
4
1,2
3†
Yuan Zhang , Mengfan Sun , Zhimin Bian *, and Jun Xu *
1,2
1,2
5
1,2
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
2 China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital
Medical University, Beijing, China
3 National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical
Sciences, Beijing Hospital/National Center of Gerontology, Beijing, China
4 Department of Gastrointestinal Surgery/Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical
University, Beijing, China
5 Comprehensive Department, National Cancer Center, Cancer Hospital, Chinese Academy of
Medical Sciences, Beijing, China

Abstract
Advances in diagnostic and therapeutic strategies have significantly contributed to
an increase in the survival rate of cancer patients. Recently, several studies suggested
that cancer patients may exhibit symptoms of cognitive impairment before, during
and even many years after the completion of therapies, negatively impacting the
quality of life and functional independence of cancer survivors. Clinically, the
† These authors contributed equally coexistence of cancer and cognitive impairment reminds scientists of paraneoplastic
to this work.
syndrome, especially limbic encephalitis. However, some cancer patients show
*Corresponding authors: symptoms of cognition deterioration after treatment, without any typical psychiatric
Zhimin Bian
(bzm_0019@sina.com symptoms, epileptic seizures or positive antineuronal antibodies, suggesting that the
Jun Xu relationship between cancer and cognitive deficits is more common than previously
(neurojun@126.com) anticipated. Most importantly, many aspects of the association between cancer and
Citation: Jiang J, Du Z, Wang Y, cognitive impairment remain uncertain. The definitive connection between systemic
et al., 2022, Advances in the study cancer and central nervous system is yet to be established. Therefore, this review
of the pathogenesis of cancer- summarizes the current evidence on the potential pathophysiology in these patients
related cognitive impairment. Tumor
Discov, 1(1): 46. with cancer-related cognitive impairment, and reviews the knowledge gaps and the
https://doi.org/10.36922/td.v1i1.46 potential counteracting strategies.
Received: December 2, 2021
Accepted: March 7, 2022
Published Online: March 22, 2022 Keywords: Cancer; Cognitive impairment; Mechanism; Chemotherapy
Copyright: © 2022 Author(s).
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution 1. Introduction
License, permitting distribution,
and reproduction in any medium, Both cancer and cognitive impairment are diseases showing extremely high incidence
provided the original work is
[1]
properly cited. and morbidity rates in China. A report published in 2019 by Zhou et al. on the
population health status of 34 provincial administrative regions in China between 1990
Publisher’s Note: AccScience
Publishing remains neutral with and 2017 indicated that lung and liver cancers ranked among the top five causes of
regard to jurisdictional claims in reduction in life expectancy. A recent cross-sectional study that included 46,011 people
published maps and institutional
affiliations. aged ≥60 years in China showed that the incidence rates of mild cognitive impairment

Volume 1 Issue 1 (2022) 1 https://doi.org/10.36922/td.v1i1.46