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Tumor Discovery

ORIGINAL RESEARCH ARTICLE
Identification of BAK1 as a novel prognostic

biomarker for liver cancer based on the mining
of liver cancer pyroptosis-related genes

1
Yiyang Chen , Wanbang Zhou , Yiju Gong , and Xi Ou *
1
2
1
1 Anhui Medical University, Hefei City, Anhui Province, 230032, China
2 Peking University Shenzhen Hospital, Futian District, Shenzhen, Guangdong, 518036, China

Abstract
Hepatocellular carcinoma is a type of digestive tract cancer that has a high incidence
and a poor prognosis. Pyroptosis, a newly discovered and proven method of pro-
inflammatory programmed cell death, is linked to tumor development, patient
prognosis, and response to therapy. In this study, the prognostic genes of liver cancer
were obtained; their expressions were extracted from The Cancer Genome Atlas
database; differential analysis, survival analysis, and clinical correlation analysis were
performed; and a nomogram was constructed to predict the survival rate. Based on
the expression of BAK1 gene, all samples were then divided into two groups: High
expression and low expression. Enrichment analysis, immunological analysis, and
drug susceptibility analysis of differential genes were subsequently performed in that
order. BAK1 expression was found to be significantly higher in liver hepatocellular
carcinoma (LIHC). High BAK1 expression levels were found to be linked to cancer
development and poor prognosis. To assess the diagnostic value of BAK1 in LIHC, a
receiver operating characteristic curve was drawn. In addition, there were significant
*Corresponding author:
Xi Ou differences in drug sensitivity between high and low BAK1 expression in 90 drugs.
(bdszyyox@163.com) The BAK1 gene may be a good potential LIHC diagnostic marker, an oncogene in
Citation: Chen Y, Zhou W, Gong Y, the occurrence and progression of liver cancer, a new prognostic biomarker, and a
et al., 2022, Identification of BAK1 potential therapeutic target for liver cancer.
as a novel prognostic biomarker for
liver cancer based on the mining
of liver cancer pyroptosis-related Keywords: BAK1; Liver cancer; Pan-cancer; Immunity; Biomarkers; Prognosis
genes. Tumor Discov, 1(2): 221.
https://doi.org/10.36922/td.v1i2.221
Received: October 13, 2022
Accepted: November 15, 2022
Published Online: December 8, 2022 1. Introduction
Copyright: © 2022 Author(s). Hepatocellular carcinoma is a type of digestive tract cancer that has a high incidence
This is an Open Access article and a poor prognosis. In recent years, the survival rate of liver cancer has improved due
distributed under the terms of the
Creative Commons Attribution to the use of surgical resection as the primary treatment method and the development
License, permitting distribution, of immunotherapy . Despite continuous advancements in medical technology, in
[1]
and reproduction in any medium,
provided the original work is the face of rising incidence, it is difficult to detect liver cancer in the early stages, and
[2]
properly cited. once it occurs, it metastasizes easily and has a poor prognosis . Liver cancer is also
Publisher’s Note: AccScience one of the leading causes of cancer-related death, and the overall 5-year survival rate
Publishing remains neutral with for patients with liver cancer remains <15% [3,4] . Therefore, novel diagnostic markers for
regard to jurisdictional claims in
published maps and institutional liver cancer are urgently needed to improve the present therapeutic environment for
affiliations. liver cancer. Pyroptosis is a newly discovered and proven method of programmed cell

Volume 1 Issue 2 (2022) 1 https://doi.org/10.36922/td.v1i2.221