Page 85 - TD-3-4
P. 85
Tumor Discovery RNA-protein complexes deregulated in cancer
Consent for publication 10. Chakravarty AK, Mcgrail DJ, Lozanoski TM, et al.
Biomolecular condensation: A new phase in cancer research.
Not applicable. Cancer Discov. 2022;12:2031-2043.
Availability of data doi: 10.1158/2159-8290.CD-21-1605
Not applicable. 11. Silva JL, Foguel D, Ferreira VF, et al. Targeting biomolecular
condensation and protein aggregation against cancer. Chem
Further disclosure Rev. 2023;123(14):9094-9138.
doi: 10.1021/acs.chemrev.3c00131
Part of the work has been presented in the virtual
conference “International Forum on Traditional and 12. Kilgore HR, Young RA. Learning the chemical
Alternative Medicine” on November 16, 2023. grammar of biomolecular condensates. Nat Chem Biol.
2022;18(12):1298-1306.
References doi: 10.1038/s41589-022-01046-y
1. Boeynaems S, Alberti S, Fawzi NL, et al. Protein phase 13. Maqsood Q, Sumrin A, Saleem MZ, et al. An insight into
separation: A new phase in cell biology. Trends Cell Biol. cancer from biomolecular condensates. Cancer Screen
2018;28(6) 420-435. Prevent. 2023;2(3):177-190.
doi: 10.1016/j.tcb.2018.02.004 doi: 10.14218/CSP.2023.00018
2. Banani SF, Lee HO, Hyman AA, Rosen MK. Biomolecular 14. Ginell GM, Holehouse AS. An introduction to the
condensates: Organizers of cellular biochemistry. Nat Rev stickers-and-spacers framework applied to biomolecular
Mol Cell Biol. 2017;18(5):285-298. condensates. Methods Mol Biol. 2023;2563:95-116.
doi: 10.1038/nrm.2017.7 doi: 10.1007/978-1-0716-2663-4_4
3. Guillén-Boixet J, Kopach A, Holehouse AS, et al. RNA- 15. Otis JP, Mowry KL. Hitting the mark: Localization of mRNA
induced conformational switching and clustering of and biomolecular condensates in health and disease. Wiley
G3BP drive stress granule assembly by condensation. Cell. Interdiscipl Rev RNA. 2023;14(6):e1807.
2020;181:346-361.e17. doi: 10.1002/wrna.1807
doi: 10.1016/j.cell.2020.03.049 16. Villegas JA, Heidenreich M, Levy ED. Molecular and
4. Rhine K, Odeh HM, Shorter J, Myong S. Regulation of environmental determinants of biomolecular condensate
biomolecular condensates by Poly(ADP-ribose). Chem Rev. formation. Nat Chem Biol. 2022;18(12):1319-1329.
2023;123(14):9065-9093. doi: 10.1038/s41589-022-01175-4
doi: 10.1021/acs.chemrev.2c00851 17. Schmidt HB, Görlich D. Transport selectivity of the nuclear
5. Fay MM, Anderson PJ. The role of RNA in biological phase pores, phase separation, and membraneless organelles.
separations. J Mol Biol. 2018;430(23):4685-4701. Trends Biochem Sci. 2016;41(1):46-61.
doi: 10.1016/j.jmb.2018.05.003 doi: 10.1016/j.tibs.2015.11.001
6. Lavalée M, Curdy N, Laurent C, Fournié JJ, Franchini DM. 18. Forman-Kay JD, Ditlev JA, Nosella ML, Lee HO. What
Cancer cell adaptability: Turning ribonucleoprotein granules are the distinguishing features and size requirements of
into targets. Trends Cancer. 2021;7(10):902-915. biomolecular condensates and their implications for RNA-
containing condensates? RNA. 2022;28:36-47.
doi: 10.1016/j.trecan.2021.05.006
doi: 10.1261/rna.079026.121
7. Taniue K, Akimitsu N. Aberrant phase separation and
cancer. FEBS J. 2022;289(1):17-39. 19. Kwon I, Kato M, Xiang S, et al. Phosphorylation-regulated
binding of RNA polymerase II to fibrous polymers of low-
doi: 10.1111/febs.15765 complexity domains. Cell. 2013;155(5):1049.
8. Mullard A. Biomolecular condensates pique drug discovery doi: 10.1016/j.cell.2013.10.033
curiosity. Nat Rev Drug Discov. 2019;18:324-326.
20. Peran I, Mittag T. Molecular structure of the biomolecular
doi: 10.1038/d41573-019-00069-w condensates. Curr Opin Struct Biol. 2020;60:17-26.
9. Conti BA, Oppikofer M. Biomolecular condensates: New doi: 10.1016/j.sbi.2019.09.007
opportunities for drug discovery and RNA therapeutics. 21. Holmes KJ, Klass DM, Guiney EL, Cyert MS. Whi3, an S.
Trends Pharmacol Sci. 2022;43(10):820-837.
cerevisiae RNA-binding protein, is a component of stress
doi: 10.1016/j.tips.2022.07.001 granules that regulates levels of its target mRNAs. PLoS One.
Volume 3 Issue 4 (2024) 26 doi: 10.36922/td.4657

