Page 52 - TD-4-1
P. 52

Tumor Discovery                                                                       WDR4 in cancer



               2022;15(1):63.                                     novel biomarker promoting cancer cell proliferation in lung
                                                                  adenocarcinoma. Front Oncol. 2022;12:1055605.
               doi: 10.1186/s13045-022-01285-5
                                                                  doi: 10.3389/fonc.2022.1055605
            8.   Cai M, Yang C, Wang Z. N7-methylguanosine modification:
               From regulatory roles to therapeutic implications in cancer.   19.  Duan HP, Yan JH, Nie L, Wang Y, Xie H. A noval prognostic
               Am J Cancer Res. 2023;13(5):1640-1655.             signature of the N7-methylguanosine (m7G)-related miRNA
                                                                  in lung adenocarcinoma. BMC Pulm Med. 2023;23(1):14.
            9.   Du D, He J, Ju C,  et al. When N -methyladenosine
                                             7
               modification meets cancer: Emerging frontiers and      doi: 10.1186/s12890-022-02290-7
               promising  therapeutic  opportunities.  Cancer  Lett.   20.  Chen J, Li K, Chen J, et al. Aberrant translation regulated
               2023;562:216165.
                                                                  by METTL1/WDR4-mediated tRNA N7-methylguanosine
               doi: 10.1016/j.canlet.2023.216165                  modification drives head and neck squamous cell carcinoma
                                                                  progression. Cancer Commun (Lond). 2022;42(3):223-244.
            10.  Wang  YT,  Chen  RH.  PML  degradation  fosters  an
               immunosuppressive  and   pro-metastatic  tumor     doi: 10.1002/cac2.12273
               microenvironment. Mol Cell Oncol. 2017;4(6):e1364212.
                                                               21.  Xu F, Cai D, Liu S,  et al. N7-methylguanosine regulatory
               doi: 10.1080/23723556.2017.1364212                 genes well represented by METTL1 define vastly different
                                                                  prognostic, immune and therapy landscapes in adrenocortical
            11.  Singh S, Yeat NY, Wang YT, et al. PTPN23 ubiquitination
               by WDR4 suppresses EGFR and c-MET degradation to   carcinoma. Am J Cancer Res. 2023;13(2):538-568.
               define  a  lung  cancer  therapeutic  target.  Cell Death Dis.   22.  Zhai Q, Hou Y, Ye Y, et al. Expression pattern and prognostic
               2023;14(10):671.                                   value of key regulators for N7-methylguanosine RNA
                                                                  modification in prostate cancer. Acta Biochim Biophys Sin
               doi: 10.1038/s41419-023-06201-4
                                                                  (Shanghai). 2023;55(4):561-573.
            12.  Xia P, Zhang H, Xu K, et al. MYC-targeted WDR4 promotes
               proliferation, metastasis, and sorafenib resistance by      doi: 10.3724/abbs.2023017
               inducing CCNB1 translation in hepatocellular carcinoma.   23.  Mei W, Jia X, Xin S, et al. A N -methylguanine-related gene
                                                                                        7
               Cell Death Dis. 2021;12(7):691.                    signature applicable for the prognosis and microenvironment
                                                                  of prostate cancer. J Oncol. 2022;2022:8604216.
               doi: 10.1038/s41419-021-03973-5
                                                                  doi: 10.1155/2022/8604216
            13.  Wang  YT,  Chen  J,  Chang  CW,  et al.  Ubiquitination of
                                                                                           7
               tumor suppressor PML regulates prometastatic and   24.  Han  H,  Yang  C,  Ma  J,  et al.  N -methylguanosine  tRNA
               immunosuppressive tumor microenvironment. J Clin Invest.   modification promotes esophageal squamous cell carcinoma
               2017;127(8):2982-2997.                             tumorigenesis via the RPTOR/ULK1/autophagy axis.  Nat
                                                                  Commun. 2022;13(1):1478.
               doi: 10.1172/JCI89957
                                                                  doi: 10.1038/s41467-022-29125-7
            14.  Huang M, Long J, Yao Z,  et al. METTL1-Mediated m7G
               tRNA modification promotes lenvatinib resistance in   25.  He S, Zhu J, Xiao Z,  et al. WDR4 gene polymorphisms
               hepatocellular carcinoma. Cancer Res. 2023;83(1):89-102.  increase hepatoblastoma susceptibility in girls.  J  Cancer.
                                                                  2022;13(12):3342-3347.
               doi: 10.1158/0008-5472.CAN-22-0963
                                                                  doi: 10.7150/jca.76255
            15.  Zhu S, Wu Y, Zhang X, et al. Targeting N -methylguanosine
                                             7
               tRNA modification blocks hepatocellular carcinoma   26.  Deng L, Hua RX, Deng C, et al. WDR4 gene polymorphisms
               metastasis after insufficient radiofrequency ablation.  Mol   and Wilms tumor susceptibility in Chinese children: A five-
               Ther. 2023;31(6):1596-1614.                        center case-control study. J Cancer. 2023;14(8):1293-1300.
               doi: 10.1016/j.ymthe.2022.08.004                   doi: 10.7150/jca.83747
            16.  Dong R, Wang C, Tang B,  et  al. WDR4 promotes HCC   27.  Jain BP, Pandey S. WD40 repeat proteins: Signalling scaffold
                                  7
               pathogenesis through N -methylguanosine by regulating   with diverse functions. Protein J. 2018;37(5):391-406.
               and interacting with METTL1. Cell Signal. 2024;118:111145.
                                                                  doi: 10.1007/s10930-018-9785-7
               doi: 10.1016/j.cellsig.2024.111145
                                                               28.  Alexandrov  A,  Martzen  MR,  Phizicky  EM.  Two  proteins
            17.  Ma J, Han H, Huang Y,  et  al. METTL1/WDR4-mediated   that form a complex are required for 7-methylguanosine
               m(7)G tRNA modifications and m(7)G codon usage     modification of yeast tRNA. RNA. 2002;8(10):1253-1266.
               promote mRNA translation and lung cancer progression.      doi: 10.1017/s1355838202024019
               Mol Ther. 2021;29(12):3422-3435.
                                                               29.  Li J, Wang L, Hahn Q, et al. Structural basis of regulated
               doi: 10.1016/j.ymthe.2021.08.005
                                                                  m G tRNA modification by METTL1-WDR4.  Nature.
                                                                    7
            18.  Liu Y, Jiang B, Lin C, et al. m7G-related gene NUDT4 as a   2023;613(7943):391-397.

            Volume 4 Issue 1 (2025)                         44                                doi: 10.36922/td.5830
   47   48   49   50   51   52   53   54   55   56   57