Page 7 - TD-4-1

Volume 4 ǀ Issue 1 ǀ March 2025 ǀ Page 1 – 131 ǀ

Tumor Discovery

https://accscience.com/journal/TD

CONTENTS

REVIEW ARTICLES
1 EpCAM-targeting cancer immunotherapies: Evidence from clinical studies and the way
forward
Dennis Makafui Dogbey, Ursula-Claire Andong-Koung-Edzidzi, Gomolemo Atlegang Molope, Jesmika Singh, Tatenda
Lovemore Bvudzijena, Krupa Naran, Stefan Barth
14 Immunocytochemistry profiling of ovarian cysts: A review of its clinical utility, future
direction, and challenges
Owajioniro Godstime Mordecai, Yibala Ibor Oboma, Raphael Teme
27 Cyclin-dependent kinase 4/6 inhibitor resistance mechanisms and strategies for subsequent
treatment in breast cancer: A comprehensive review
Yuling Zhang, Bingfeng Chen, Rendong Zhang, Jundong Wu, Chunfa Chen
37 WD repeat domain 4 in tumorigenesis: Molecular mechanisms, cancer-type specific roles,
and therapeutic potential
Xun Zou, Ling Tao, Bin Liu

ORIGINAL RESEARCH ARTICLES
47 Systemic drug repurposing for pancreatic cancer based on genetic and epigenetic network
analysis using a systems biology approach and deep neural learning of drug-target
interactions
Yi-Hsin Tsai, Bor-Sen Chen
68 Molecular characterization of colorectal cancer: Insights from miRNA, mRNA, and protein
analysis
Hersh Abdul Ham-Karim, Narmeen Ahmad, Alan Shwan, Mohammad Ilyas
79 Covalent docking-based virtual screening and molecular dynamics simulations identify C02b
as a potential KRAS(G12C) inhibitor
Safiye Merve Bostancioglu, Ahmet Acar
99 Homoharringtonine inhibits pancreatic cancer progression via mitochondrial energy
metabolism suppression and macrophages reduction
Xiaoxia Wang, Tao Wang, Xuelu Peng, Ke Zhu, Ming Ye, Jie Meng, Haiyan Xu

CASE REPORTS
113 Efficacy of pyrotinib and capecitabine in recurrent breast cancer with a HER2-negative
genetic switch following systemic therapy: A case report and literature review
Yuling Zhang, Bingfeng Chen, Jundong Wu, Chunfa Chen
120 Biallelic MUTYH gene mutation resulting in fluoropyrimidine-resistant advanced rectal
cancer: A case report
Tawasapon Thambamroong, Chawanya Rabiltossaporn
125 Clinical presentation and demographic characteristics of polypoid melanoma on the back: A
case study
Emmanuel Angel Zappettini, Sergio Fernández Vértiz

LETTER TO EDITOR
129 Dosiomics in lung cancer
Melek Yakar

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