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Artificial Intelligence in Health                                       AI in AD – Diagnosis and monitoring



            respondents thought that automated suggestions for   resources for AI models. 97-99  These datasets often consist of
            diagnosing skin tumors had strong or very strong   lesions that have been confirmed by pathology, follow-up
            potential in terms of diagnostic categorization, whereas   examinations, expert consensus, or  in vivo confocal
            42.6% thought that automated detection of mitosis had the   microscopy, which enhances their reliability.
            highest potential. 93,94
                                                                 Prudent consideration is crucial for researchers involved
              Patients typically know little about AI than medical   in the development of AI programs, especially when facing
            professionals. In a qualitative study conducted from May   challenges related to training datasets. Estimating the
            to July 2019, involving 48  patients and semi-structured   optimal number of training images can be challenging, as
            interviews for analysis, around 60% of participants   having an insufficient dataset may compromise the quality
            stated that shorter diagnosis times and easier access to   of the program, while an excessively large dataset runs the
            healthcare were the two biggest advantages of AI for skin   risk of overfitting the ML classifier to the data, limiting its
            cancer  surveillance.  Nonetheless,  40%  of  participants   applicability to external datasets. It is important to note that
            expressed concerns about potential dangers, including a   advanced mathematical techniques are available to address
            rise in patient anxiety. The patients identified the major   these challenges, such as dropout, data augmentation,
            benefits and drawbacks of AI as the ability to deliver more   batch  normalization,  and  others. 92,100,101   These  methods
            precise diagnoses (33 [69%]) and less precise diagnoses   play a key role in preventing overfitting and ensuring
            (41 [85%]). Notably, 35 out of 75 patients stated that they   the robustness and generalizability of the AI program,
                                               95
            would recommend AI to friends and family.  In summary,   which holds significant clinical relevance from a scientific
            pathologists and dermatologists generally hold an   perspective. Efficient utilization of the dataset is crucial in
            optimistic view of the prospective advantages and effects   achieving the desired accuracy for specific classifications.
            of AI in the field of dermatology. However, only a minority   In addition, the dataset should include a diverse range of
            of respondents within the cohort exhibited a good or   images from various demographics to ensure that resulting
            exceptional comprehension of AI. While most pathologists   algorithms  have  external  validity. 102,103   When  acquiring
            expect AI to be most useful in specific tasks rather than   images, it is important to consider potential systematic
            offering overall automated diagnostic advice, a majority   errors such as variations in lighting, tools, or processes,
            of dermatologists believe that AI will improve diagnostic   particularly in different clinical settings, to maintain the
            capabilities. Overall, only a small percentage (1 – 3%) of   research’s validity beyond its original context. Simplifying
            pathologists and dermatologists express concern that AI   the program’s classifications to those with significant
            may soon replace them. As long as AI is used in a way   prognostic implications can help reduce the size of the
            that maintains the doctor-patient relationship, patients are   dataset and the complexity of algorithms. 102,104
            amenable to using it to monitor skin conditions.
                                                                 Randomized clinical trials must be carried out to
            12. Perspectives and conclusion                    evaluate the potential of new computer methods and DL
            The potential of AI in the field of AD presents an opportunity   in large-scale investigations. Given the limited research
            to  significantly  enhance  diagnostic  accuracy  and provide   in this area, these studies are especially important for
            personalized healthcare. However, several aspects must   gathering data on therapeutic benefits and assisting with
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            be addressed before this innovative approach can be   causal inference.  Moreover, addressing unmet demands
            seamlessly integrated into routine clinical practice. AI is   such as cost-effectiveness and safety concerns is critical
            gaining recognition at a pace in the field of dermatology,   before transferring AI technology from research to clinical
            with researchers increasingly focusing on developing AI   settings. Robust regulatory procedures are required to
            programs that require diverse data sources for training   guarantee the safe handling and preservation of private
            purposes. These data sources include clinical patient data,   information.  Another  important  challenge  is  ensuring
            which encompasses various aspects such as demographics,   AI-based healthcare is equitable and inclusive. Healthcare
            comorbidities, characteristics of skin lesions, and relevant   AI should be trained and validated using population-
            laboratory  and  imaging  findings.  Furthermore,  molecular   representative data to achieve generalizable performance
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            profiles obtained from biopsy data, such as proteomic   levels.  It is crucial to take into account social and health
            analysis, provide valuable information.  Another avenue   inequalities that can exclude kids from particular groups
                                           5,96
            involves utilizing data from existing literature. Finally, images   who typically have limited access to care. Relying mostly
            play a crucial role in the analysis and classification process.   on data from majority ethnic groups or patients with
            Notably, publicly available benchmarking image datasets   high socioeconomic status could introduce bias into
            such as the International Skin Imaging Collaboration and   AI performance, as the system may pick up diagnostic
            PH2 dermoscopic archives serve as instrumental training   tendencies from these over-represented groups. 107


            Volume 1 Issue 2 (2024)                         59                               doi: 10.36922/aih.2775
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