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Advanced Neurology Inflammation and gut microbiota in depression

mechanisms by which stress triggers leaky gut and BBB Availability of data
damage remain unclear. Changes in the composition of
gut microbiota have been observed in animal models and Not applicable.
also in patients with depression, but the causal relationship References
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Acknowledgments https://doi.org/10.1016/S1474-4422(15)70016-5
6. De Virgilio A, Greco A, Fabbrini G, et al., 2016, Parkinson’s
The schematic diagrams were created with BioRender.com. disease: Autoimmunity and neuroinflammation.
Autoimmun Rev, 15: 1005–1111.
Funding
https://doi.org/10.1016/j.autrev.2016.07.022
This work was supported by the Science and Technology
Innovation 2030-Major Project of the Ministry of Science and 7. Troubat R, Barone P, Leman S, et al., 2021, Neuroinflammation
and depression: A review. Eur J Neurosci, 53: 151–171.
Technology of China (2021ZD0202904/2021ZD0202900),
the National Natural Science Foundation of Distinguished https://doi.org/10.1111/ejn.14720
Young Scholars (82025033), the National Natural Science 8. Raison CL, Capuron L, Miller AH, 2006, Cytokines sing the
Foundation of China (82230115), and the Fundamental blues: inflammation and the pathogenesis of depression.
Research Funds for the Central Universities (1124007125). Trends Immunol, 27: 24–31.

Conflict of interest https://doi.org/10.1016/j.it.2005.11.006
9. Musselman DL, Lawson DH, Gumnick JF, et al., 2001,
The authors declare that they have no conflicts of interest. Paroxetine for the prevention of depression induced by
high-dose interferon alfa. N Engl J Med, 344: 961–966.
Author contributions
https://doi.org/10.1056/NEJM200103293441303
Conceptualization: Yang Cai, Honghong Yao
Supervision: Honghong Yao 10. Haapakoski R, Mathieu J, Ebmeier KP, et al., 2015, Cumulative
Writing – original draft: Yang Cai, Sibo Zhao meta-analysis of interleukins 6 and 1beta, tumour necrosis
factor alpha and C-reactive protein in patients with major
Writing – review & editing: Yang Cai, Shenyang Zhang, depressive disorder. Brain Behav Immun, 49: 206–215.
Honghong Yao.
https://doi.org/10.1016/j.bbi.2015.06.001
Ethics approval and consent to participate
11. Kappelmann N, Lewis G, Dantzer R, et al., 2018, Antidepressant
Not applicable. activity of anti-cytokine treatment: A systematic review
and meta-analysis of clinical trials of chronic inflammatory
Consent for publication conditions. Mol Psychiatry, 23: 335–343.
Not applicable. https://doi.org/10.1038/mp.2016.167

Volume 1 Issue 3 (2022) 9 https://doi.org/10.36922/an.v1i3.272