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Advanced Neurology eGFR and serum neurofilament light chain

Table 5. Subgroup analysis some limitations. First, the cross-sectional design of our
study limits our ability to establish causality between eGFR,
Variables β (95% CI [upper P‑value P for
limit, lower limit]) interaction sNfL levels, and hypertension. Longitudinal studies are
Age (years) 0.44 needed to better understand the temporal relationship and
potential causal pathways. Second, our study focused on
<60 −0.17 (−0.24, −0.10) <0.01 a specific time frame and the American adult population.
≥60 −0.36 (−0.75, 0.04) 0.07 The results may not be fully generalized to other regions or
Sex 0.39 age groups, and variations in health-care systems, genetics,
Female −0.17 (−0.27, −0.06) 0.01 and lifestyles should be considered. For further research,
Male −0.23 (−0.41, −0.05) 0.02 conducting longitudinal studies with multiple time points
BMI (kg/m ) 0.21 would allow for tracking changes in all variables, providing
2
<5 −0.17 (−0.30, −0.03) 0.02 more insight into the causal relationship and potential
25–30 −0.09 (−0.19, 0.01) 0.07 predictive value. What’s more, comparing the utility of
≥30 −0.20 (−0.34, −0.06) 0.01 sNfL with other established biomarkers in assessing kidney
Hypertension 0.01 function and neurological damage could provide a broader
context for the potential clinical applications of sNfL. In
No −0.05 (−0.09, −0.01) 0.02 conclusion, our findings emphasize the significance of
Yes −0.33 (−0.50, −0.15) 0.01 considering both kidney function and hypertension status
DM 0.45 when evaluating sNfL levels.
No −0.14 (−0.26, −0.02) 0.02
Yes −0.40 (−0.61, −0.18) 0.01 5. Conclusion
CKD 0.57 Our findings emphasize the significance of considering
No −0.15 (−0.33, 0.03) 0.10 both kidney function and hypertension status when
Yes −0.30 (−0.54, −0.07) 0.01 evaluating sNfL levels. Our research demonstrates a strong
Abbreviations: BMI: Body mass index; CI: Confidence interval; CKD; relationship between the eGFR and sNfL. To summarize,
Chronic kidney disease; DM; Diabetes mellitus. our study reveals a negative correlation between eGFR and
sNfL levels in the adult population, with a turning point at
Moreover, a recent cross-sectional study demonstrated an eGFR of 59.9. These findings contribute to the growing
that diabetes was associated with elevated sNfL levels, and body of literature highlighting the potential utility of sNfL
this correlation remained significant even after accounting as a biomarker for kidney function and hypertension-
for related covariates . Coincidentally, Maalmi et al. induced neurological damage. Future research could
[28]
[27]
have also identified sNfL as a potential novel biomarker for explore whether monitoring sNfL levels facilitates the
early diabetic sensorimotor polyneuropathy. In light of these monitoring of kidney disease progression.
findings, we included diabetes mellitus in our subgroup
analysis and found no significant interaction with eGFR. Acknowledgments
The inclusion of diabetes mellitus in the subgroup analysis We thanked all the researchers and participants of the
and the absence of a significant interaction offer valuable NHANES study for their critical review and profound
insights. This observation suggests that while diabetes contributions.
may contribute to elevated sNfL levels, its interaction with
eGFR may differ from that of hypertension. This nuanced Funding
distinction prompts us to explore the distinct molecular
pathways through which diabetes impacts neuronal health. None.
This distinction holds the potential to tailor interventions
aimed at customizing neuroprotection strategies for Conflict of interest
individuals with varying comorbidities. The author declares that the research was conducted in the
A recent study has demonstrated that urine sNfL absence of any commercial or financial relationships that
could effectively differentiate between individuals with could be construed as a potential conflicts of interest.
neuronal damage and those without . This non-invasive Author contributions
[29]
and fast detection method could be valuable for detecting
neurological damage. Nevertheless, our study still has This is a single-authored article.

Volume 2 Issue 3 (2023) 7 https://doi.org/10.36922/an.1394