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Advanced Neurology eGFR and serum neurofilament light chain

Table 1. (Continued)
Variables Total eGFR P‑value
Q1 Q2 Q3 Q4
Stroke (n [%]) 0.04
No 2019 (97.49) 493 (95.79) 507 (98.12) 505 (96.84) 514 (99.65)
Yes 52 (2.51) 25 (4.21) 10 (1.88) 14 (3.16) 3 (0.35)
DM (n [%]) <0.01
No 1820 (87.88) 413 (83.88) 458 (90.92) 460 (91.08) 489 (95.20)
Yes 251 (12.12) 105 (16.12) 59 (9.08) 59 (8.92) 28 (4.80)
Drink (n [%]) 0.02
Never 253 (12.22) 65 (10.13) 60 (11.02) 65 (9.71) 63 (11.46)
Former 295 (14.24) 108 (16.70) 82 (12.92) 67 (11.21) 38 (6.60)
Now 1360 (65.67) 315 (68.21) 348 (71.94) 337 (70.86) 360 (73.29)
Missing 163 (7.87) 30 (4.96) 27 (4.12) 50 (8.22) 56 (8.66)
Notes: Q1 (1.86–82.82), Q2 (82.82–98.39), Q3 (98.39–111.39), Q4 (111.39–159.93). *Including divorced, separated, widowed; Including married,
#
living with partner. BMI: Body mass index; CKD: Chronic kidney disease; DM: Diabetes mellitus; eGFR: Estimated glomerular filtration rate;
HF: Heart failure; MetS: Metabolic syndrome; MI: Myocardial infarction.

Table 2. Univariate analysis for sNfL Table 2. (Continued)
Variables β (95% CI [upper P‑value Variables β (95% CI [upper P‑value
limit, lower limit]) limit, lower limit])
Age (years) 0.38 (0.27, 0.49) <0.01 Hypertension
BMI (kg/m ) 0.09 (−0.05, 0.23) 0.19 No 1.00 (ref)
2
Sex Yes 9.4 (4.37, 14.43) 0.01
Female 1.00 (ref) MetS
Male 2.02 (−0.30, 4.34) 0.08 No 1.00 (ref)
Marital Yes 6.82 (2.72, 10.93) 0.01
Never 1.00 (ref) Smoke
Alone* 6.26 (0.64, 11.88) 0.03 Never 1.00 (ref)
Partner # 2.57 (0.62, 4.52) 0.01
Former 5.42 (−0.35, 11.20) 0.06
Education
<High school 1.00 (ref) Now 2.37 (−0.01, 4.75) 0.05
High school 0.61 (−3.54, 4.75) 0.76 Stroke
>High school 0.9 (−2.91, 4.70) 0.62 No 1.00 (ref)
CKD Yes 24.97 (−16.08, 66.02) 0.21
No 1.00 (ref) DM
Yes 10.42 (5.50, 15.34) <0.01 No 1.00 (ref)
HF Yes 12.82 (5.20, 20.43) 0.01
No 1.00 (ref) Drink
Yes 11.98 (2.96, 21.01) 0.01 Never 1.00 (ref)
MI Former 6.12 (−4.89, 17.12) 0.25
No 1.00 (ref) Now −2.78 (−8.16, 2.60) 0.28
Yes 9.56 (1.47, 17.64) 0.02 eGFR (ml/min/1.73 m ) −0.31 (−0.42, −0.19) <0.01
2
Hyperlipidemia Notes: *Including divorced, separated, widowed; Including married,
#
No 1.00 (ref) living with partner. BMI: Body mass index; CI: Confidence interval;
Yes 5.19 (1.35, 9.03) 0.01 CKD: Chronic kidney disease; DM: Diabetes mellitus; eGFR: Estimated
glomerular filtration rate; HF: Heart failure; MetS: Metabolic syndrome; MI:
(Cont’d...) Myocardial infarction; sNfL: Serum neurofilament light chain.

Volume 2 Issue 3 (2023) 5 https://doi.org/10.36922/an.1394