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Advanced Neurology

ORIGINAL RESEARCH ARTICLE
Estimated glomerular filtration rate and serum

neurofilament light chain: Insight from National
Health and Nutrition Examination Survey

Jiangwen Liu*

Department of Cardiology, 928 Hospital of Joint Logistics Support Force of PLA, Haikou, 571100,
Hainan, China

Abstract

The neurofilament light chain is a protein biomarker associated with
neurodegenerative diseases. Neurofilament light chain levels may increase as kidney
function declines due to reduced clearance. However, the relationship between
estimated glomerular filtration rate (eGFR) and serum neurofilament light chain (sNfL)
has not been extensively studied. Therefore, the objective of this study was to examine
the association between eGFR and sNfL levels. Health survey data from 2071 eligible
participants in the National Health and Nutrition Examination Survey (NHANES) were
used in three multivariate-adjusted weighted linear regression models to analyze the
correlation between eGFR and sNfL. Subsequently, segmental linear regression analysis
was employed to determine the inflection point of eGFR. Finally, through subgroup
analysis, we aimed to assess the impact of all covariates on the association between
eGFR and sNfL. According to our results, sNfL levels decreased as eGFR increased.
*Corresponding author: The segmental linear regression model analysis identified an inflection point at 59.9.
Jiangwen Liu
(2020203020029@whu.edu.cn) When eGFR reached 59.9 or exceeded it, each unit increase in eGFR was associated
with a 1 pg/mL decrease in sNfL (β = −0.1, P = 0.01). Furthermore, subgroup analysis
Citation: Liu J, 2023, Estimated
glomerular filtration rate and serum revealed that hypertension exhibited a significant interaction with the association
neurofilament light chain: Insight between eGFR and sNfL (P = 0.01). These findings suggest that eGFR holds promise
from National Health and Nutrition as a potential marker for neurodegenerative disorders, and hypertension could
Examination Survey. Adv Neuro,
2(3): 1394. affect this association to some extent. Moreover, these results could have significant
https://doi.org/10.36922/an.1394 implications for the early detection and prevention of neurodegenerative diseases
in patients with kidney disease. However, further research is needed to corroborate
Received: July 26, 2023
these results and elucidate the underlying mechanisms.
Accepted: September 14, 2023
Published Online: September 27,
2023 Keywords: Estimated glomerular filtration rate; Serum neurofilament light chain; Kidney;
National Health and Nutrition Examination Survey
Copyright: © 2023 Author(s).
This is an Open-Access article
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution, 1. Introduction
and reproduction in any medium,
provided the original work is Kidney disease and neurological disorders are increasingly prevalent and debilitating
properly cited. health problems worldwide. The kidneys serve a critical role in filtering and eliminating
Publisher’s Note: AccScience waste products from the blood , while the nervous system governs and coordinates all
[1]
Publishing remains neutral with bodily functions . Despite their distinct functions, recent evidence suggests a correlation
[2]
regard to jurisdictional claims in
[3]
published maps and institutional between kidney function and neurological health . One potential biomarker that has
affiliations. emerged as a promising indicator of both kidney and neurological health is the serum
Volume 2 Issue 3 (2023) 1 https://doi.org/10.36922/an.1394