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Advanced Neurology                                                               BTKi in brain diseases



            BTK inhibitors in brain diseases, especially considering   2001;23(2-3):147-156.
            that BTK inhibitors can enter and accumulate within      doi: 10.1385/IR:23:2-3:147
            the CNS, where they can directly affect immune cells.
            Overall, therapeutic targeting of BTK in brain diseases   5.   Woyach JA, Johnson AJ, Byrd JC. The B-cell receptor
            shows promise and warrants further investigations. Future   signaling pathway as a therapeutic target in CLL.  Blood.
                                                                  2012;120(6):1175-1184.
            works may focus on the development of BTK inhibitors
            as effective treatments for various brain diseases, which      doi: 10.1182/blood-2012-02-362624
            could provide additional valuable therapeutic options for   6.   Frischer JM, Bramow S, Dal-Bianco A, et al. The relation
            patients.                                             between inflammation and neurodegeneration in multiple
                                                                  sclerosis brains. Brain. 2009;132(Pt 5):1175-1189.
            Acknowledgments
                                                                  doi: 10.1093/brain/awp070
            None.                                              7.   Rolli V, Gallwitz M, Wossning T, et al. Amplification of B cell

            Funding                                               antigen receptor signaling by a Syk/ITAM positive feedback
                                                                  loop. Mol Cell. 2002;10(5):1057-1069.
            None.                                                 doi: 10.1016/s1097-2765(02)00739-6

            Conflict of interest                               8.   Whang JA, Chang BY. Bruton’s tyrosine kinase inhibitors for
                                                                  the treatment of rheumatoid arthritis. Drug Discov Today.
            The authors declare that they have no competing interests.  2014;198:1200-1204.

            Author contributions                                  doi: 10.1016/j.drudis.2014.03.028
            Conceptualization: Qiang Liu, Han Jin              9.   Pal Singh S, Dammeijer F, Hendriks RW. Role of Bruton’s
                                                                  tyrosine kinase in B cells and malignancies.  Mol Cancer.
            Writing – original draft: Hongying Hao                2018;17(1):57.
            Writing – review & editing: Qiang Liu, Han Jin
                                                                  doi: 10.1186/s12943-018-0779-z
            Ethics approval and consent to participate         10.  Martin E, Aigrot MS, Grenningloh R, et al. Bruton’s tyrosine
            Not applicable.                                       kinase inhibition promotes myelin repair.  Brain Plast.
                                                                  2020;5(2):123-133.
            Consent for publication                               doi: 10.3233/bpl-200100
            Not applicable.                                    11.  Keaney J, Gasser J, Gillet G, Scholz D, Kadiu I. Inhibition of
                                                                  Bruton’s tyrosine kinase modulates microglial phagocytosis:
            Availability of data                                  Therapeutic  implications  for  Alzheimer’s  disease.  J
            Not applicable.                                       Neuroimmune Pharmacol. 2019;143:448-461.
                                                                  doi: 10.1007/s11481-019-09839-0
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            Volume 3 Issue 1 (2024)                         7                         https://doi.org/10.36922/an.2184
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