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Advanced Neurology X chromosome-mediated risk in Alzheimer’s disease

The new directions proposed by the present research doi: 10.1212/WNL.0b013e31828726f5
may lead to an improved understanding of the transmission 2. D’errico P, Meyer-Luehmann M. Mechanisms of pathogenic
of familial LOAD and the role played by the X chromosome. Tau and Aβ protein spreading in Alzheimer’s disease. Front
Aging Neurosci. 2020;12:265.
Acknowledgments
doi: 10.3389/fnagi.2020.00265
None.
3. Soreq L, Bird H, Mohamed W, Hardy J. Single-cell RNA
Funding sequencing analysis of human Alzheimer’s disease brain
samples reveals neuronal and glial specific cells differential
This research was funded by the National Institute of Health expression. PLoS One. 2023;18(2):e0277630.
National Institute on Aging 1 (RF1 AG054052-01). Partial doi: 10.1371/journal.pone.0277630
support for all data sets within the UPDB was provided
by the Huntsman Cancer Institute, Huntsman Cancer 4. Bellenguez C, Grenier-Boley B, Lambert JC. Genetics of
Foundation, the University of Utah, and the Huntsman Alzheimer’s disease: Where we are, and where we are going.
Cancer Institute’s Cancer Center Support Grant (P30 Curr Opin Neurobiol. 2020;61:40-48.
CA42014) from the National Cancer Institute. L.A.C.-A. doi: 10.1016/j.conb.2019.11.024
received support from the Huntsman Cancer Foundation 5. Guerreiro R, Wojtas A, Bras J, et al. TREM2 variants in
and George E. Wahlen Department of Veterans Affairs Alzheimer’s disease. N Engl J Med. 2013;368:117-127.
Medical Center, Salt Lake City, Utah.
doi: 10.1056/NEJMoa1211851
Conflict of interest 6. Cannon-Albright LA, Foster NL, Schliep K, et al. Relative
The authors declare no conflicts of interest. risk for Alzheimer disease based on complete family history.
Neurology. 2019;92:e1745-e1753.
Author contributions doi: 10.1212/WNL.0000000000007231
Conceptualization: Carmel Armon, Lisa A. Cannon- 7. Edland SD, Silverman JM, Peskind ER, Tsuang D,
Albright, Sharon Wolfson Wijsman E, Morris JC. Increased risk of dementia in
Investigation: Carmel Armon mothers of Alzheimer’s disease cases: Evidence for maternal
Methodology: Carmel Armon, Sharon Wolfson inheritance. Neurology. 1996;47:254-246.
Writing–original draft: Carmel Armon, Lisa A. Cannon- doi: 10.1212/wnl.47.1.254
Albright
Writing–review & editing: Kristina Allen-Brady, Sharon 8. Honea RA, Swerdlow RH, Vidoni ED, Burns JM. Progressive
regional atrophy in normal adults with a maternal history of
Wolfson Alzheimer disease. Neurology. 2011;76:822-829.
Ethics approval and consent to participate doi: 10.1212/WNL.0b013e31820e7b74

The study was approved by the University of Utah 9. Honea RA, Vidoni ED, Swerdlow RH, Burns JM, Alzheimer’s
Institutional Review Board and the Utah Resource Disease Neuroimaging Initiative. Maternal family history is
for Genetic Epidemiological Research (approval no.: associated with Alzheimer’s disease biomarkers. J Alzheimers
Dis. 2012;31:659-668.
IRB_00057751), which collectively oversee the use of
UPDB data. Individual consent was not required to access doi: 10.3233/JAD-2012-120676
the data or to publish. 10. Roberts RO, Geda YE, Knopman DS, et al. The incidence
of MCI differs by subtype and is higher in men: The mayo
Consent for publication clinic study of aging. Neurology. 2012;78:342-351.
Not applicable. doi: 10.1212/WNL.0b013e3182452862

Availability of data 11. Mielke MM, Vemuri P, Rocca WA. Clinical epidemiology of
Alzheimer’s disease: Assessing sex and gender differences.
Access to UPDB data are allowed with appropriate Clin Epidemiol. 2014;6:37-48.
application and approval.
doi: 10.2147/CLEP.S37929
References 12. Bajic VP, Essack M, Zivkovic L, et al. The X Files: “The
mystery of X chromosome instability in Alzheimer’s
1. Herbert LE, Weuve J, Scherr PA, Evans DA. Alzheimer
disease in the United States (2010-2050) estimated using the disease”. Front Genet. 2020;10:1368.
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Volume 3 Issue 2 (2024) 9 doi: 10.36922/an.3122