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Advanced Neurology Fatigue management in patients with MS

Table 2. Review of the effect of exercise on fatigue in patients with multiple sclerosis
Study Intervention Proven effectiveness Outcome analysis
Kooshiar et al. 37 Aquatic exercise Yes (i) Effective in reducing physical and psychosocial fatigue.
(ii) Not effective on cognitive fatigue perception.
Kerling et al. 38 Short-term endurance Yes Short-term endurance or a combination of endurance/resistance
or combined endurance/ exercises are both effective in reducing fatigue.
resistance exercise
Razazian et al. 39 Yoga and aquatic exercise Yes (i) The superiority of yoga and aquatic exercise was shown compared
to the control group.
(ii) Both types of exercise are effective in reducing symptoms of
fatigue, depression, and paresthesia.
Dehkordi 40 Yoga and aerobic exercise Yes In addition to fatigue, it significantly increases the psychosocial
well-being of the patient.
Bulguroglu et al. 41 Mat Pilates and reformer Pilates Yes Both types of plates have been reported to be effective in reducing fatigue.
Heine et al. 42 Aerobic exercise Yes It has a positive effect on fatigue, but it was not found to be clinically significant.
Kargarfard et al. 43 Aquatic exercise Yes It improved patients’ functional capacity and perception of balance
along with fatigue.
Grazioli et al. 44 Simultaneous resistance and Yes Improvement in patients’ walking and balance ability, reduction in
aerobic exercise depression, fatigue and disease severity, and improvement in quality
of life have been reported.
Callesen et al. 45 Resistance training and balance Yes Resistance training and balance and motor control training are both
and motor control training effective in reducing fatigue.
Feys et al. 46 Physical activity program Yes In addition to fatigue, it has been reported to improve aerobic
capacity, functional mobility, visuospatial memory, fatigue, quality of
life, and pallidum volume.
Plow et al. 47 Telephone-delivered Yes This teleconference intervention has a minor but statistically
physical activity and fatigue significant effect on fatigue reduction.
self-management program
Young et al. 48 Movement-to-music Yes (i) Effective in reducing fatigue compared to the control group.
(ii) It is a fun way to improve walking and endurance.
Kratz et al. 49 Telephone-delivered exercise Yes (i) It is an effective method to reduce fatigue.
ıntervention (ii) It is recommended to be tested in larger groups.
Abonie & Hettinga 50 Tailored Activity Pacing Yes Adapting activity pace to physical activity behaviors and fatigue is
Intervention effective in improving physical activity levels without exacerbating
fatigue symptoms.
Akbar et al. 51 Progressive resistance Yes (i) Significant increases in functional connectivity between the
exercise program caudate and left inferior parietal, bilateral frontal, and right insula
of the brain were reported in individuals undergoing PRT.
(ii) Greater post-training increases in functional connectivity between
the caudate and left inferior parietal region were associated with
greater reductions in cognitive fatigue in particular.
Ozdogar et al. 52 Video-based exergaming Yes It has been reported to be more effective in improving upper and lower
extremity function, cognitive function and quality of life, and reducing
fatigue and depression compared to conventional exercise therapy.
Fleming et al. 53 Home-based Pilates Yes It is effective in reducing anxiety and depression as well as fatigue.
Alketbi et al. 54 Cognition-targeted exercise Yes Cognition-targeted exercise has been reported to be more effective in
versus symptom-targeted exercise reducing fatigue.
Langeskov- High-intensity aerobic Yes A clinically significant effect on fatigue was found.
Chiristensen et al. 55 exercise
Bilek et al. 56 Aerobic exercise Yes (i) Reduces the level of depression along with fatigue.
(ii) Increases the serum level of irisin
Karpatkin et al. 57 Intermittent Yes Intermittent walking is a superior form of exercise in reducing
walking-continuous walking fatigue and increasing walking volume.
Pan et al. 58 Baduanjin-yoga exercise Yes Baduanjin practice is reported to be more effective than yoga and
suitable for MS patients.
Rad & Aghayari 59 Sensory-motor exercise Yes (i) It has been reported to improve static balance as well as fatigue.
program (ii) However, no significant effect on dynamic balance was found.
Wolf et al. 60 Multimodal agility-based Yes Both exercises are reported to be effective in reducing motor fatigue,
exercise training versus strength but they may worsen cognitive fatigue.
and endurance training

Volume 3 Issue 2 (2024) 4 doi: 10.36922/an.2576