Page 23 - AN-3-2

Advanced Neurology Fatigue management in patients with MS

Table 4. Studies investigating the effects of other non‑pharmacological methods on fatigue in patients with MS
Study Intervention Proven effectiveness Outcome analysis
Bastani et al. 82 Acupressure Yes (i) It is an effective and safe method.
(ii) It should be studied in larger groups.
Choobforoushzadeh Neurofeedback training Yes (i) It has been shown to be an effective method for reducing both
et al. 83 fatigue and depression when compared to the control group.
(ii) Its effectiveness lasts for up to 2 months.
Blikman et al. 80 Individual energy conservation No The study has not demonstrated the superiority of the method over
management (ECM) the control group.
Akker et al. 84 Cognitive behavioral therapy Yes (i) It is effective in reducing severe fatigue in the short term.
(ii) More studies are needed to understand its effect in the long term.
Gonzales et al. 85 Body cooling Yes (i) It is an effective method to reduce fatigue and improve physical
activity performance.
Pöttgen et al. 86 Self-guided interventions Yes (ii) It is a cost-effective and efficient method for reducing fatigue.
Cancelli et al. 87 Transcranial direct stimulation Yes Bilateral whole-body somatosensory cortex stimulation is effective
in reducing fatigue.
Charvet et al. 88 Transcranial direct current Yes Dorsolateral prefrontal cortex left anodal tDCS is an effective
stimulation method to reduce fatigue.
Chalah et al. 89 Transcranial direct stimulation Yes It has been reported that this method is effective in reducing
symptoms of anxiety and fatigue.
Mortezanejad et al. 90 Anodal transcranial direct Yes (i) Its superiority over the placebo group has been demonstrated.
current stimulation (a-tDCS) (ii) However, the effectiveness of it is short-lived, lasting only four weeks.
Mateen et al. 91 Light therapy Yes Headache has been reported as a side effect.
Radecka et al. 92 Whole body cryotherapy Yes It reduces fatigue and improves functional status.
Ghannadi et al. 93 Respiratory muscle training Yes Exercise training that strengthens respiratory muscles has been
reported to significantly improve respiratory function, reduce
fatigue, and enhance quality of life.
Yeni et al. 94 Self-administered acupressure Yes (i) No side effects have been reported.
(ii) It has been reported that this method is effective and safe.
Moustafaa et al. 95 Computer-based cognitive Yes (i) Computer-based cognitive therapy is more effective in reducing
training fatigue than a standard physiotherapy program.
(ii) Enhances cognitive abilities and reduces the level of
inflammatory biomarkers.
Askari et al. 96 One-on-one coaching sessions Yes (i) It is an effective program to reduce fatigue.
with web-based (ii) It should be studied in larger groups.
(iii) It is an intervention with low cost and no side effects.
Granja- Dominiquez Low-frequency pulsed Yes (i) Fatigue was significantly reduced in patients who received PEMF
et al. 97 electromagnetic field (PEMF) therapy compared to the placebo group.
therapy (ii) It is effective in improving walking performance and quality of
life, as well as reducing levels of depression.
Silva et al. 81 Photobiomodulation No No effect on fatigue has been reported.
Kesik et al. 98 Relaxation techniques Yes (i) Progressive muscle relaxation was found to be more effective than
the Benson relaxation technique.
(ii) However, both methods are effective in reducing fatigue, pain,
and kinesiophobia.
(iii) There are no side effects.
Gier et al. 99 Cognitive behavioral therapy Yes (i) Cognitive behavioral therapy (CBT) can be offered online if it
(CBT) cannot be delivered in person. CBT is effective in reducing fatigue.
(ii) Face-to-face CBT is not superior to online therapy.
(iii) Mixed CBT, which combines face-to-face and online
components, can save time and space.
Qomi et al. 100 Nurse-led fatigue management Yes It has been found to be effective in improving sleep quality and
self-efficacy, and reducing fatigue.
Khodaie et al. 101 Acupuncture Yes Acupuncture combined with amantadine is an effective method for
reducing fatigue.
Titcomb et al. 102 Web-based program for the Yes The web-based program for adopting wellness behaviors, implemented
adoption of wellness behaviors without personalized support, is highly effective in reducing fatigue.
Motl et al. 103 Behavioral intervention Yes (i) Behavioral intervention can effectively reduce fatigue.
(ii) Its positive effects on other patient outcomes should be evaluated
in future studies.
Gay et al. 104 Cognitive behavioral therapy Yes Cognitive behavioral therapy is more effective than standard care in
reducing fatigue.

Volume 3 Issue 2 (2024) 6 doi: 10.36922/an.2576