Page 7 - AN-3-4

Advanced Neurology

REVIEW ARTICLE
Incidence and prevalence of Lewy body

dementia in India: A systematic review

1
Harshini Priya Kirushnakumar * , Niranjana Mohan 2 , and
Joseph P. M. Kane 3
1 Department of Psychiatry, Lincolnshire Partnership NHS Foundation Trust, Boston, Lincolnshire,
United Kingdom
2 Northern Ireland Medical and Dental Training Agency, Belfast, Ireland, United Kingdom
3 Centre for Public Health, Queen’s University Belfast, United Kingdom

Abstract

With increasing life expectancy in India, the prevalence of age-related disorders,
such as dementia has also increased. Health and social care resources for each state
are allocated based on their inhabitants’ age, sex, education, and urban/rural status
but not on the dementia subtype, which can significantly influence prognosis,
healthcare utilization, and quality of life. Herein, we aimed to systematically review
studies investigating the prevalence of the Lewy body dementia (LBD) subtype in
India. We conducted a systematic review of EMBASE, MEDLINE, and APA PsychINFO
databases on June 22, 2023. Two independent reviewers performed screening and
full-text review, with a third reviewer resolving any disputes. Quality was assessed for
each extracted paper. Of 1372 identified studies, full-text reviews were conducted
*Corresponding author: on 399 and data were extracted from 4. Two studies included prevalence data
Harshini Priya Kirushnakumar on dementia with Lewy bodies (DLB), one on Parkinson’s disease dementia and
(harshinipriya.kirushnakumar@nhs. one on LBD. DLB or LBD has been reported to represent 1.0 – 8.9% of dementia
net)
diagnoses. Methodological heterogeneity was characterized by study design, access
Citation: Kirushnakumar HP, to biomarkers, diagnostic criteria, and use of cognitive tools. No studies reported
Mohan N, Kane JPM. Incidence and
prevalence of Lewy body dementia incidence data. A paucity of research on LBD epidemiology in India is compounded
in India: A systematic review. Adv by methodological heterogeneity, poorly representative cohorts, and varying
Neurol. 2024;3(4):4098. access to biomarkers. Consensus guidelines may support data harmonization and
doi: 10.36922/an.4098 the creation of multisite consortia, which could redress the under-representation of
Received: July 1, 2024 Central Asian data in epidemiological and genetic LBD studies.
Accepted: August 26, 2024
Published Online: October 10, Keywords: Lewy body dementia; Dementia with Lewy bodies; Parkinson’s disease
2024 dementia; Prevalence; Incidence; India
Copyright: © 2024 Author(s).
This is an Open-Access article
distributed under the terms of the
Creative Commons Attribution 1. Introduction
License, permitting distribution,
and reproduction in any medium,
provided the original work is India, with a population of over 1.4 billion, surpassed China as the world’s most populous
1
properly cited. country in 2023. The life expectancy in India has consistently increased over the past
1
Publisher’s Note: AccScience six decades, from 42.9 years in 1960 to 70.4 years in 2020. Because of the increasing age of
Publishing remains neutral with the Indian population, age-related disorders, such as dementia, are expected to increase.
1
regard to jurisdictional claims in In 2010, the Alzheimer’s and Related Disorders Society of India estimated that 3.7 million
published maps and institutional
2
affiliations. Indians are living with dementia, but recently published nationally representative data
Volume 3 Issue 4 (2024) 1 doi: 10.36922/an.4098