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Advanced Neurology Lipid droplets and neurodegenerative disorders

Figure 1. Biogenesis of LDs. Triacylglycerol is synthesized within the ER. LDs formation happens within the ER bilayer. After budding, the nascent LDs
are separated from the ER and become matured organelles. Image created by the authors using Biorender.
Abbreviations: DGAT: Diacylglycerol acyltransferase; ER: Endoplasmic reticulum; FITs: Fat storage-inducing transmembrane protein; LDs: Lipid
droplets; PLIN: Perilipin.

Figure 2. Pathophysiology of LDs in neurons, microglia, and astrocytes. There are various lipids crosstalk, including neuron-to-glia and glia-to-neuron,
among these cells in the brain. Image created by the authors using Biorender.
Abbreviations: ApoE: Apolipoprotein E; LDs: Lipid droplets; TREM2: Triggering receptor expressed on myeloid cells 2.

by neuron through LDL receptor. 17,18 Abnormal delivery of of axon regeneration and synaptogenesis. Importantly,
cholesterol from neuroglia to neurons may result in defect lipids can also be transported from neuron to other

Volume 4 Issue 2 (2025) 3 doi: 10.36922/an.5060