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Advanced Neurology Lipid droplets and neurodegenerative disorders

the spatiotemporal alteration of LDs. Second, given the for lipid droplets in a stem cell niche of Drosophila. Cell.
complexity and diversity of cell types in CNS, a deeper 2015;163(2):340-353.
investigation into the functions of LDs in different cell doi: 10.1016/j.cell.2015.09.020
types and transport crosstalk across neuroglia-to-neuron
or neuron-to-neuroglia can enrich our understanding of 4. Liu L, Zhang K, Sandoval H, et al. Glial lipid droplets
and ROS induced by mitochondrial defects promote
the comprehensive regulatory roles of LDs in CNS. Finally, neurodegeneration. Cell. 2015;160(1-2):177-190.
whether LDs can serve as a rational therapeutic target for
improving the consequence of NDDs in the future requires doi: 10.1016/j.cell.2014.12.019
additional research. For clinical application, the detection 5. Zhang Y, Chen Y, Zhuang C, et al. Lipid droplets in the
method of LDs should be more sensitive and specific. As nervous system: Involvement in cell metabolic homeostasis.
for LDs-based therapeutics, it should be noted that LDs Neural Regen Res. 2025;20(3):740-750.
may have both protective and detrimental functions in the doi: 10.4103/NRR.NRR-D-23-01401
brain cells. How to maintain the balance of maximizing the
protective role or minimizing the detrimental role of LDs 6. Garcia K, Alves A, Ribeiro-Rodrigues TM, Reis F, Viana S.
would be a challenging but meaningful work to deal with. Analysis of fluorescent-stained lipid droplets with 3D
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Acknowledgments Exp. 2023;19(6):e65206.
The authors thank Zoe Zhang for valuable feedback on the doi: 10.3791/65206
manuscript. All figures were created by BioRender.com. 7. Hsia JZ, Liu D, Haynes L, Cruz-Cosme R, Tang Q. Lipid
droplets: Formation, degradation, and their role in
Funding cellular responses to flavivirus infections. Microorganisms.
2024;12(4):647.
None.
doi: 10.3390/microorganisms12040647
Conflict of interest 8. Thiam AR, Farese RV Jr., Walther TC. The biophysics

The authors declare no conflicts of interest. and cell biology of lipid droplets. Nat Rev Mol Cell Biol.
2013;14(12):775-786.
Author contributions doi: 10.1038/nrm3699

Conceptualization: All authors 9. Zhang Z, Yu Z, Liang D, et al. Roles of lipid droplets and
Visualization: Wan-Di Xiong related proteins in metabolic diseases. Lipids Health Dis.
Writing–original draft: Xin-Yi Chen, Ting-ting Fu 2024;23(1):218.
Writing–review & editing: All authors doi: 10.1186/s12944-024-02212-y
Ethic approval and consent to participate 10. Thiam AR, Ikonen E. Lipid droplet nucleation. Trends Cell
Not applicable. Biol. 2021;31(2):108-118.

Consent for publication doi: 10.1016/j.tcb.2020.11.006
11. Santinho A, Salo VT, Chorlay A, et al. Membrane curvature
Not applicable. catalyzes lipid droplet assembly. Curr Biol. 2020;30(13):

Availability of data 2481-2494.e6.
doi: 10.1016/j.cub.2020.04.066
Not applicable.
12. Han S, Binns DD, Chang YF, Goodman JM. Dissecting seipin
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