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Advanced Neurology                                              Lipid droplets and neurodegenerative disorders



            14.  Madsen  S, Delgado  AC, Cadilhac C,  et al.  A  fluorescent      doi: 10.1016/j.immuni.2017.08.008
               perilipin 2 knock-in mouse model reveals a high abundance   25.  Marschallinger J, Iram T, Zardeneta M, et al. Lipid-droplet-
               of lipid droplets in the developing and adult brain.  Nat   accumulating microglia represent a dysfunctional and
               Commun. 2024;15(1):5489.
                                                                  proinflammatory state in the aging brain.  Nat Neurosci.
               doi: 10.1038/s41467-024-49449-w                    2020;23(2):194-208.
            15.  Ramosaj M, Madsen S, Maillard V,  et al. Lipid droplet      doi: 10.1038/s41593-019-0566-1
               availability affects neural stem/progenitor cell metabolism
               and proliferation. Nat Commun. 2021;12(1):7362.  26.  Haney MS, Palovics R, Munson CN, et al. APOE4/4 is linked
                                                                  to damaging lipid droplets in Alzheimer’s disease microglia.
               doi: 10.1038/s41467-021-27365-7                    Nature. 2024;628(8006):154-161.
            16.  Liu L, MacKenzie KR, Putluri N, Maletic-Savatic M, Bellen HJ.      doi: 10.1038/s41586-024-07185-7
               The glia-neuron lactate shuttle and elevated ROS promote
               lipid synthesis in neurons and lipid droplet accumulation in   27.  Litvinchuk A, Suh JH, Guo JL, et al. Amelioration of
               glia via APOE/D. Cell Metab. 2017;26(5):719-737.e6.  Tau and ApoE4-linked glial lipid accumulation and
                                                                  neurodegeneration with an LXR agonist.  Neuron.
               doi: 10.1016/j.cmet.2017.08.024                    2024;112(3):384-403.e388.
            17.  Lee JA, Hall B, Allsop J, Alqarni R, Allen SP. Lipid      doi: 10.1016/j.neuron.2023.10.023
               metabolism in astrocytic structure and function. Semin Cell
               Dev Biol. 2021;112:123-136.                     28.  Huang H, Xiang R, Yan R. Linking APOE4/4 genotype to
                                                                  microglial lipid droplets and neurotoxicity in Alzheimer’s
               doi: 10.1016/j.semcdb.2020.07.017                  disease. Transl Neurodegener. 2024;13(1):38.
            18.  Mauch DH, Nagler K, Schumacher S,  et al. CNS      doi: 10.1186/s40035-024-00433-w
               synaptogenesis promoted by glia-derived cholesterol.
               Science. 2001;294(5545):1354-1357.              29.  Garcia Corrales AV, Haidar M, Bogie JFJ, Hendriks JJA.
                                                                  Fatty acid synthesis in glial cells of the CNS. Int J Mol Sci.
               doi: 10.1126/science.294.5545.1354                 2021;22(15):8159.
            19.  Lipke K, Kubis-Kubiak A, Piwowar A. Molecular mechanism      doi: 10.3390/ijms22158159
               of lipotoxicity as an interesting aspect in the development
               of pathological states-current  view of  knowledge.  Cells.   30.  Vicente-Gutierrez C, Jimenez-Blasco D, Quintana-Cabrera R.
               2022;11(5):844.                                    Intertwined ROS and metabolic signaling at the neuron-
                                                                  astrocyte interface. Neurochem Res. 2021;46(1):23-33.
               doi: 10.3390/cells11050844
                                                                  doi: 10.1007/s11064-020-02965-9
            20.  Prinz M, Jung S, Priller J. Microglia biology: One century of
               evolving concepts. Cell. 2019;179(2):292-311.   31.  Bak LK, Walls AB, Schousboe A, Waagepetersen HS.
                                                                  Astrocytic glycogen metabolism in the healthy and diseased
               doi: 10.1016/j.cell.2019.08.053                    brain. J Biol Chem. 2018;293(19):7108-7116.
            21.  Nugent AA, Lin K, van Lengerich B, et al. TREM2 regulates      doi: 10.1074/jbc.R117.803239
               microglial cholesterol metabolism upon chronic phagocytic
               challenge. Neuron. 2020;105(5):837-854.e9.      32.  Smolic T, Tavcar P, Horvat A,  et al. Astrocytes in stress
                                                                  accumulate lipid droplets. Glia. 2021;69(6):1540-1562.
               doi: 10.1016/j.neuron.2019.12.007
                                                                  doi: 10.1002/glia.23978
            22.  Kunjathoor VV, Tseng AA, Medeiros  LA, Khan T,
               Moore KJ. beta-Amyloid promotes accumulation of lipid   33.  Pacheco P, Bozza FA, Gomes RN, et al. Lipopolysaccharide-
               peroxides by inhibiting CD36-mediated clearance of   induced leukocyte lipid body formation  in vivo: Innate
               oxidized lipoproteins. J Neuroinflammation. 2004;1(1):23.  immunity elicited intracellular Loci involved in eicosanoid
                                                                  metabolism. J Immunol. 2002;169(11):6498-6506.
               doi: 10.1186/1742-2094-1-23
                                                                  doi: 10.4049/jimmunol.169.11.6498
            23.  Cantuti-Castelvetri L, Fitzner D, Bosch-Queralt M,  et al.
               Defective cholesterol clearance limits remyelination in   34.  Khatchadourian A, Bourque SD, Richard VR, Titorenko VI,
               the  aged central nervous system.  Science. 2018;359(6376):   Maysinger  D.  Dynamics  and  regulation  of  lipid  droplet
               684-688.                                           formation in lipopolysaccharide (LPS)-stimulated microglia.
                                                                  Biochim Biophys Acta. 2012;1821(4):607-617.
               doi: 10.1126/science.aan4183
                                                                  doi: 10.1016/j.bbalip.2012.01.007
            24.  Krasemann S, Madore C, Cialic R,  et al. The TREM2-
               APOE pathway drives the transcriptional phenotype of   35.  Buchanan MM, Hutchinson M, Watkins LR, Yin H. Toll-like
               dysfunctional microglia in neurodegenerative diseases.   receptor 4 in CNS pathologies. J Neurochem. 2010;114(1):
               Immunity. 2017;47(3):566-581.e9.                   13-27.


            Volume 4 Issue 2 (2025)                         9                                doi: 10.36922/an.5060
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