Page 20 - AN-4-3

Advanced Neurology Stem cell therapy in stroke treatment: Advances and prospects

medicine. Biomolecules. 2019;10(1):48. 74. Rosado-de-Castro PH, Schmidt FR, Battistella V, et al.
Biodistribution of bone marrow mononuclear cells after
doi: 10.3390/biom10010048
intra-arterial or intravenous transplantation in subacute
64. Song H, Chen X, Hao Y, Wang J, Xie Q, Wang X. stroke patients. Regen Med. 2013;8(2):145-155.
Nanoengineering facilitating the target mission:
Targeted extracellular vesicles delivery systems design. doi: 10.2217/rme.13.2
J Nanobiotechnol. 2022;20(1):431. 75. Chen DC, Lin SZ, Fan JR, et al. Intracerebral implantation
of autologous peripheral blood stem cells in stroke
doi: 10.1186/s12951-022-01638-9
patients: A randomized phase II study. Cell Transplant.
65. Li RK, Yau TM, Weisel RD, et al. Construction of a 2014;23(12):1599-1612.
bioengineered cardiac graft. J Thorac Cardiovasc Surg.
2000;119(2):368-375. doi: 10.3727/096368914X678562
76. Vahidy FS, Haque ME, Rahbar MH, et al. Intravenous bone
doi: 10.1016/S0022-5223(00)70193-0
marrow mononuclear cells for acute ischemic stroke: Safety,
66. Frith JE, Thomson B, Genever PG. Dynamic three- feasibility, and effect size from a phase I clinical trial. Stem
dimensional culture methods enhance mesenchymal stem Cells. 2019;37(11):1481-1491.
cell properties and increase therapeutic potential. Tissue
Eng. Part C Methods. 2010;16(4):735-749. doi: 10.1002/stem.3080
77. Friedrich MA, Martins MP, Araújo MD, et al. Intra-arterial
doi: 10.1089/ten.TEC.2009.0432
infusion of autologous bone marrow mononuclear cells in
67. Ghali AA, Yousef MK, Ragab OA, ElZamarany EA. Intra- patients with moderate to severe middle cerebral artery acute
arterial infusion of autologous bone marrow mononuclear ischemic stroke. Cell Transplant. 2012;21(1_suppl):13-21.
stem cells in subacute ischemic stroke patients. Front Neurol. doi: 10.3727/096368912X612512
2016;7:228.
78. Kitamura T, Terashima T, Katagi M, Ohashi N, Nozaki K,
doi: 10.3389/fneur.2016.00228
Tsuji A. Bone marrow-derived mononuclear cells ameliorate
68. Polymeri A, Giannobile WV, Kaigler D. Bone marrow neurological function in chronic cerebral infarction model
stromal stem cells in tissue engineering and regenerative mice via improvement of cerebral blood flow. Cytotherapy.
medicine. Horm Metab Res. 2016;48(11):700-713. 2023;25(11):1186-1199.
doi: 10.1055/s-0042-118458 doi: 10.1016/j.jcyt.2023.07.003
69. Rastegar F, Shenaq D, Huang J, et al. Mesenchymal stem 79. Boese AC, Le QS, Pham D, Hamblin MH, Lee JP. Neural
cells: Molecular characteristics and clinical applications. stem cell therapy for subacute and chronic ischemic stroke.
World J Stem Cells. 2010;2(4):67. Stem Cell Res Ther. 2018;9:1-7.
doi: 10.4252/wjsc.v2.i4.67 doi: 10.1186/s13287-018-0913-2
70. Nicaise C, Mitrecic D, Falnikar A, Lepore AC. 80. Bhasin A, Srivastava MP, Mohanty S, et al. Paracrine
Transplantation of stem cell-derived astrocytes for the mechanisms of intravenous bone marrow-derived
treatment of amyotrophic lateral sclerosis and spinal cord mononuclear stem cells in chronic ischemic stroke.
injury. World J Stem Cells. 2015;7(2):380. Cerebrovasc Dis Extra. 2017;6(3):107-119.
doi: 10.4252/wjsc.v7.i2.380 doi: 10.1159/000446404
71. Salaudeen MA, Bello N, Danraka RN, Ammani ML. 81. Karlupia N, Manley NC, Prasad K, Schäfer R, Steinberg GK.
Understanding the pathophysiology of ischemic stroke: The Intraarterial transplantation of human umbilical cord blood
basis of current therapies and opportunity for new ones. mononuclear cells is more efficacious and safer compared
Biomolecules. 2024;14(3):305. with umbilical cord mesenchymal stromal cells in a rodent
stroke model. Stem cell Res Ther. 2014;5:1-9.
doi: 10.3390/biom14030305
doi: 10.1186/scrt434
72. Prust ML, Forman R, Ovbiagele B. Addressing disparities
in the global epidemiology of stroke. Nat Rev Neurol. 82. Chrostek MR, Fellows EG, Crane AT, Grande AW, Low WC.
2024;20(4):207-221. Efficacy of stem cell-based therapies for stroke. Brain Res J.
2019;1722:146362.
doi: 10.1038/s41582-023-00921-z
doi: 10.1016/j.brainres.2019.146362
73. Turnbull MT, Zubair AC, Meschia JF, Freeman WD.
Mesenchymal stem cells for hemorrhagic stroke: Status 83. Abe K. Therapeutic potential of neurotrophic factors and
of preclinical and clinical research. NPJ Regen Med. neural stem cells against ischemic brain injury. J Cereb Blood
2019;4(1):10. Flow Metab. 2000;20(10):1393-1408.
doi: 10.1038/s41536-019-0073-8 doi: 10.1097/00004647-200010000-00001

Volume 4 Issue 3 (2025) 14 doi: 10.36922/an.5582